Results 231 to 240 of about 25,300,433 (384)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Na-Cl Cotransporter (SLC12A3) Inhibition Exacerbates Age-Related Macular Degeneration Via the Nrf2/HO-1 Ferroptosis Pathway [PDF]

Chengming Chen, Tingke Xie, Huan Zhang, Lifu Chang, Yanyan Lan, Chao Fan, Dongyu Wei, Xiaolan Wang, Sida Liu, Yixuan Chen, Yuhao Chen, Xuejiao Wang, Xiaolong Yan, Lei Shang, Liyuan Tao, Jing Han   +15 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

ROS mediate selenite-induced apoptosis in colon cancer cells

Open Life Sciences, 2010
Králová Věra, Červinka Miroslav, Rudolf Emil   +2 more
doaj   +1 more source

Betaine Inhibits Ferroptosis After Intracerebral Hemorrhage by Activating the Nrf2/HO-1 Pathway. [PDF]

Antioxidants (Basel)
Chen J, Lu X, Liu S, Hu W, Zhou X, Wang Z.   +5 more
europepmc   +1 more source

Litsea salicifolia Roxb. bark ethanolic extract attenuates rheumatoid arthritis by inhibiting TLR4/NF-κB and activating SIRT1-Nrf2/HO-1 signaling axis: In-vitro and in-vivo evaluations

, 2022
Eswara Rao Puppala, Md. Abubakar, Veerabhadra Swamy, Sai Sudha Yalamarthi, Syamprasad NP, Aruna Prakash, Jagadeesh Kumar Gangasani, D. Chamundeswari, V.G.M. Naidu   +8 more
openalex   +1 more source

GRP78 effectively protect hypoxia/reperfusion‐induced myocardial apoptosis via promotion of the Nrf2/HO‐1 signaling pathway [PDF]

, 2020
Heyu Ji, Feng Xiao, Suobei Li, Wei Ruan, Fei Yu, Junmei Xu   +5 more
openalex   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Oleanolic Acid Promotes Porcine Oocyte Maturation by Activating the Nrf2/Ho-1 Signalling Pathway

Yanqiu Wang, Yan‐Wei Dong, He‐Xuan Qu, Jiajia Qi, Chen-Xuan Yan, Hua‐Kai Wei, Hao Sun, Boxing Sun, Shuang Liang   +8 more
openalex   +1 more source

Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo [PDF]

, 2017
Xuan Zhao, Wen‐Liang Dong, Yuandi Gao, Dong-Shoo Shin, Qing Ye, Le Su, Fan Jiang, Bao‐Xiang Zhao, Jun‐Ying Miao   +8 more
openalex   +1 more source