Results 241 to 250 of about 25,300,433 (384)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis. [PDF]

Sci Rep
Ding S, Hu D, Pan Y, Wang J, Wang L.
europepmc   +1 more source

Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy

, 2023
Liang-Hsuan Chien, Jeng‐Shyan Deng, Wen‐Ping Jiang, Ya-Ni Chou, Jaung‐Geng Lin, Guan‐Jhong Huang   +5 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway. [PDF]

Mol Med Rep
Hsia CH, Yang CM, Chang CC, Yen TL, Darmanto AG, Huang CC, Sheu JR.   +6 more
europepmc   +1 more source

Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice

Yunfei Luo, Shaohua Sun, Yuying Zhang, Shuang Liu, Haixia Zeng, J.F. Li, Jiadian Huang, Lei Fang, Shiqi Yang, Yu Peng, Jianping Liu   +10 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Crocins Ameliorate Experimental Immune Checkpoint Inhibitor-Related Myocarditis by Targeting the Hpx/Nrf2/HO-1 Pathway. [PDF]

Int J Mol Sci
Yan J, Cai Q, Li Y, Zhang Y, Zhao Y, Zhang F, Zhang H.   +6 more
europepmc   +1 more source

Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity [PDF]

Guojin Liang, Jie Fang, Ping Zhang, Shuxia Ding, Yudan Zhao, Yueying Feng   +5 more
openalex   +1 more source

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

Laboratory Investigation, 2019
Jia Shi, Jian-bo Yu, Yuan Zhang, Li-li Wu, Shuan Dong, Lina Wu, Lingzhi Wu, Shi-Han Du, yanfang zhang, D. Ma   +9 more
semanticscholar   +1 more source