Results 271 to 280 of about 22,040,645 (295)
Some of the next articles are maybe not open access.
Neurotoxicity Research, 1999
Heme oxygenase (HO) produced biliverdin and bilirubin, which are powerful antioxidants, therefore, it has been proposed as helpful against oxidative stress. In contrast, HO also produces iron, and it could increase oxidative stress if not handled property.
Y, Matsuoka, M, Okazaki, Y, Kitamura
openaire +2 more sources
Heme oxygenase (HO) produced biliverdin and bilirubin, which are powerful antioxidants, therefore, it has been proposed as helpful against oxidative stress. In contrast, HO also produces iron, and it could increase oxidative stress if not handled property.
Y, Matsuoka, M, Okazaki, Y, Kitamura
openaire +2 more sources
An ELISA assay for heme oxygenase (HO-1)
Journal of Immunological Methods, 2001A double antibody capture ELISA for the HO-1 protein has been developed to separately quantitate HO-1 protein. The use of 2.5% NP40 detergent greatly assists in freeing HO-1 protein from membranes and/or other cellular entities and increased the amount of HO-1 protein found in rat liver whole homogenates as well as the nuclear, mitochondrial and ...
K T, Kitchin, W L, Anderson, M, Suematsu
openaire +2 more sources
Role of Nrf2 and HO-1 in intervertebral disc degeneration
Connective Tissue Research, 2022Intervertebral disc degeneration (IDD) is a common age-related disease with clinical manifestations of lumbar and leg pain and limited mobility. The pathogenesis of IDD is mainly mediated by the death of intervertebral disc (IVD) cells and the imbalance of extracellular matrix (ECM) synthesis and degradation. Oxidative stress and inflammatory reactions
Cang-Yu Zhang +5 more
openaire +2 more sources
Therapeutic Potential of HO-1 in Autoimmune Diseases
Inflammation, 2014Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule.
Bao-Zhu, Li +6 more
openaire +2 more sources
Nrf2/HO-1 as a therapeutic target in renal fibrosis
Life Sciences, 2023Chronic kidney disease (CKD) is one of the most prevalent chronic diseases and affects between 10 and 14 % of the world's population. The World Health Organization estimates that by 2040, the disease will be fifth in prevalence. End-stage CKD is characterized by renal fibrosis, which can eventually lead to kidney failure and death.
Emad H M, Hassanein +5 more
openaire +2 more sources
Neurology, 2001
Last year, we published an article in Neurology entitled “Evaluation of heme oxygenase-1 as a systemic biologic marker of sporadic AD.”1 In that article, we reported that heme oxygenase-1 (HO-1) protein concentrations are significantly lower in plasma and CSF samples procured from subjects with sporadic AD relative to normal elderly control values ...
H M, Schipper +3 more
openaire +2 more sources
Last year, we published an article in Neurology entitled “Evaluation of heme oxygenase-1 as a systemic biologic marker of sporadic AD.”1 In that article, we reported that heme oxygenase-1 (HO-1) protein concentrations are significantly lower in plasma and CSF samples procured from subjects with sporadic AD relative to normal elderly control values ...
H M, Schipper +3 more
openaire +2 more sources
HO‐1: An emerging target in fibrosis
Journal of Cellular PhysiologyAbstractFibrosis, an aberrant reparative response to tissue injury, involves a disruption in the equilibrium between the synthesis and degradation of the extracellular matrix, leading to its excessive accumulation within normal tissues, and culminating in organ dysfunction.
Chenxi Lu +7 more
openaire +2 more sources
Phytomedicine, 2022
Oxyberberine (OBB), an important in vivo metabolite of berberine, exerts superior hypoglycemia effect. However, the underlying mechanism remains obscure. Heme oxygenase-1 (HO-1) holds a crucial status in the pathogenesis of diabetes. Previous research has indicated that OBB can specifically bind to hemoglobin and significantly up-regulated the HO-1 ...
Yaoxing, Dou +8 more
openaire +2 more sources
Oxyberberine (OBB), an important in vivo metabolite of berberine, exerts superior hypoglycemia effect. However, the underlying mechanism remains obscure. Heme oxygenase-1 (HO-1) holds a crucial status in the pathogenesis of diabetes. Previous research has indicated that OBB can specifically bind to hemoglobin and significantly up-regulated the HO-1 ...
Yaoxing, Dou +8 more
openaire +2 more sources
Vascular Pharmacology, 2015
Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and carbon monoxide (CO), the latter was mostly shown to mediate many beneficial HO-1 effects, including protection against oxidative injury, regulation of apoptosis, modulation of ...
Agnieszka, Loboda +2 more
openaire +2 more sources
Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and carbon monoxide (CO), the latter was mostly shown to mediate many beneficial HO-1 effects, including protection against oxidative injury, regulation of apoptosis, modulation of ...
Agnieszka, Loboda +2 more
openaire +2 more sources
A Focus on Heme Oxygenase-1 (HO-1) Inhibitors
Current Medicinal Chemistry, 2013The aim of this review is to highlight the advances in the field of heme oxygenase-1 (HO-1) inhibitors over the past years, particularly from a medicinal chemistry point of view; progresses made in the field strongly helped to clarify physiological roles of the heme oxygenase (HO) system.
PITTALA', Valeria +4 more
openaire +3 more sources