Results 271 to 280 of about 465,102 (291)
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HO-1 Promotes Unhealthy Obesity
Science Signaling, 2014Heme oxygenase-1 promotes inflammation and insulin resistance in obesity.
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Neurotoxicity Research, 1999
Heme oxygenase (HO) produced biliverdin and bilirubin, which are powerful antioxidants, therefore, it has been proposed as helpful against oxidative stress. In contrast, HO also produces iron, and it could increase oxidative stress if not handled property.
Y, Matsuoka, M, Okazaki, Y, Kitamura
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Heme oxygenase (HO) produced biliverdin and bilirubin, which are powerful antioxidants, therefore, it has been proposed as helpful against oxidative stress. In contrast, HO also produces iron, and it could increase oxidative stress if not handled property.
Y, Matsuoka, M, Okazaki, Y, Kitamura
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2002
Transplantation is considered one of the most effective ways to overcome terminal dysfunction and failure of some organs. By transplanting organs or tissues between two genetically distinct individuals, an immune mediated response is triggered in the transplant recipient that evokes a potent inflammatory reaction, causing cell injury/death and leading ...
P. O. Berberat +4 more
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Transplantation is considered one of the most effective ways to overcome terminal dysfunction and failure of some organs. By transplanting organs or tissues between two genetically distinct individuals, an immune mediated response is triggered in the transplant recipient that evokes a potent inflammatory reaction, causing cell injury/death and leading ...
P. O. Berberat +4 more
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Vascular Pharmacology, 2015
Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and carbon monoxide (CO), the latter was mostly shown to mediate many beneficial HO-1 effects, including protection against oxidative injury, regulation of apoptosis, modulation of ...
Agnieszka, Loboda +2 more
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Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and carbon monoxide (CO), the latter was mostly shown to mediate many beneficial HO-1 effects, including protection against oxidative injury, regulation of apoptosis, modulation of ...
Agnieszka, Loboda +2 more
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A Focus on Heme Oxygenase-1 (HO-1) Inhibitors
Current Medicinal Chemistry, 2013The aim of this review is to highlight the advances in the field of heme oxygenase-1 (HO-1) inhibitors over the past years, particularly from a medicinal chemistry point of view; progresses made in the field strongly helped to clarify physiological roles of the heme oxygenase (HO) system.
PITTALA', Valeria +4 more
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HO‐1: An emerging target in fibrosis
Journal of Cellular PhysiologyAbstractFibrosis, an aberrant reparative response to tissue injury, involves a disruption in the equilibrium between the synthesis and degradation of the extracellular matrix, leading to its excessive accumulation within normal tissues, and culminating in organ dysfunction.
Chenxi Lu +7 more
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P8 deficiency increases cellular ROS and induces HO-1
Archives of Biochemistry and Biophysics, 2015The gene p8 encodes for a small cytoprotective protein with no apparent enzymatic activity being proposed to act as co-transcription factor whose expression is increased during inflammation. Recent data from astrocytes demonstrates that p8 suppression leads to induction of heme oxygenase 1 (HO-1). Here, we assessed the cross-talk between p8 and HO-1 in
Sebastian Weis +6 more
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Gastric Cancer, 2020
NRF2, a prime target of cellular defense against oxidative stress, has shown a dark side profile in cancer progression. GRIM-19, an essential subunit of the mitochondrial MRC complex I, was recently identified as a suppressive role in tumorigenesis of human gastric cancer (GC).
Xin Wang +9 more
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NRF2, a prime target of cellular defense against oxidative stress, has shown a dark side profile in cancer progression. GRIM-19, an essential subunit of the mitochondrial MRC complex I, was recently identified as a suppressive role in tumorigenesis of human gastric cancer (GC).
Xin Wang +9 more
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HO-1/HSP32 and Cardiac Stress Signaling
2019In recent years, increased attention has been gained in elucidating the therapeutic potential of heme oxygenase-1 (HO-1), a rate limiting enzyme involved in the heme metabolism and their pathophysiology of various cardiovascular diseases and heart failure models.
Lakshmikanthan Panneerselvam +3 more
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