Results 1 to 10 of about 1,405 (177)

The importance of holotranscobalamin measurement [PDF]

Journal of Medical Biochemistry, 2007
Clinically significant vitamin B12 deficiency can occur even with total vitamin B12 levels apparently within normal range. There is an indeterminate zone between approximately 154 and 300 pmol/L of vitamin B12 where there is likely misclassification of ...
Čabarkapa Velibor, Stošić Zoran, Žeravica Radmila, Ilinčić Branislava, Filipović Ana   +4 more
doaj   +4 more sources

Holotranscobalamin Concentrations Across Human Pregnancy: A Systematic Review

Current Developments in Nutrition
Leigh A Martin, Payton Forsyth, Rita Castro, Omar Lweno, Emily R Smith, Alison D Gernand   +5 more
doaj   +4 more sources

Serum Vitamin B12 and Holotranscobalamin Levels in Subclinical Hypothyroid Patients in Relation to Thyroid-Stimulating Hormone (TSH) Levels and the Positivity of Anti-thyroid Peroxidase Antibodies: A Case-Control Study. [PDF]

Cureus
Background Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels, while thyroid hormones (free thyroxine (T4) and free triiodothyronine (T3)) remain within the reference ranges.
Al-Mousawi M, Salih S, Ahmed A, Abdullah B.   +3 more
europepmc   +4 more sources

Comparing Holotranscobalamin and Total Vitamin B12 in Diagnosing Vitamin B12 Deficiency in Megaloblastic Anemia Patients. [PDF]

Cureus
Background Megaloblastic anemia is characterized by abnormally large red blood cells caused by a deficiency in either vitamin B12 or folic acid, both of which are essential for DNA synthesis.
Tufail N, Kataria M, Chaudhary AJ, Dhillon RA, Asif Naveed M, Mohsin S.   +5 more
europepmc   +4 more sources

Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke [PDF]

Disease Markers, 2021
Background Whether holotranscobalamin (holoTC) indicates B12 deficiency more sensitively than total vitamin B12 (B12) is unclear. This study is aimed at determining the impact of serum holoTC level as a risk factor for ischemic stroke and investigating ...
O. Kweon, Yong Kwan Lim, Mi-Kyung Lee, Hye Ryoun Kim   +3 more
semanticscholar   +4 more sources

Failure of the holotranscobalamin assay in vitamin B12-deficient patients [PDF]

LaboratoriumsMedizin, 2018
Background It has been demonstrated that vitamin B12 determinations fail, especially in patients with pernicious anemia with high titers of intrinsic factor antibody.
C. Knoepfel, Martine Michel Blanco, U. Nydegger, L. Risch, H. Renz, M. Risch   +5 more
semanticscholar   +3 more sources

Relationship Between the Levels of Holotranscobalamin and Vitamin B12 in Children [PDF]

Indian Journal of Hematology and Blood Transfusion, 2017
The purpose of this study was to evaluate the relationship between the plasma holoTC and serum vitamin B12 in children and to identify a cutoff cobalamin values according to holoTC. One hundred and fifty-five children were enrolled into the study. All children were evaluated for hemoglobin, vitamin B12, folate, ferritin and holoTC levels. Children were
İ. Ok Bozkaya, N. Yaralı, M. Kızılgün, S. Ozkan, B. Tunç   +4 more
semanticscholar   +7 more sources

Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics [PDF]

The Scientific World Journal, 2012
Background. Measurement of serum cobalamin (Cbl) levels is the standard investigation for assessing vitamin B12 deficiency. Falsely increased values of Cbl can be caused by alcoholic liver disease.
Alberto Fragasso, Clara Mannarella, Angela Ciancio, Oronzo Scarciolla, Nicoletta Nuzzolese, Rocco Clemente, Eustachio Vitullo, Andrea Sacco   +7 more
doaj   +5 more sources

Serum Holotranscobalamin and Methylmalonic Acid as Early Markers of Vitamin B12 Deficiency in Pregnant Females

Indian Journal of Medical Specialities
Background: Screening for Vitamin B12 deficiency in pregnancy is not routinely done in antenatal care. Serum Vitamin B12 assay has low sensitivity and specificity; therefore, this study was conducted to assess the usefulness of holotranscobalamin (HoloTC)
Fallguni Arora, Sunita Sharma, Kiran Aggarwal   +2 more
doaj   +3 more sources

Multicentre evaluation of the Roche Elecsys® Active B12 (holotranscobalamin) electro-chemiluminescence immunoassay [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2019
Background Vitamin B12 deficiency is a common disorder. In circulation, vitamin B12 is bound to transcobalamin (holotranscobalamin), which is considered the active form of cobalamin.
S. Heil, Petra Bodenburg, P. Findeisen, Silke Luebcke, Yuli Sun, Y. D. de Rijke   +5 more
semanticscholar   +5 more sources