Personalising laboratory medicine in the ‘real world’: Assessing clinical utility, by clinical indication, of serum total B12 and Active-B12® (holotranscobalamin) in the diagnosis of vitamin B12 deficiency [PDF]
Annals of Clinical Biochemistry, 2021 Background Assessing the pre- and post-test probability of disease in the context of routine health care is challenging. We wished to study how test performance parameters relating to clinical utility vary by clinical indication in a ‘real-world’ setting.
M. Murphy +6 more
semanticscholar +6 more sources
Associations of Serum Folate and Holotranscobalamin with Cardiometabolic Risk Factors in Rural and Urban Cameroon [PDF]
Nutrients, 2021 A low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations.
Camille M. Mba +6 more
semanticscholar +4 more sources
Holotranscobalamin: in the middle of difficultly lies opportunity
Clinical Chemistry and Laboratory Medicine (CCLM), 2016 D. Harrington
semanticscholar +5 more sources
Characterization of a monoclonal antibody with specificity for holo-transcobalamin [PDF]
Nutrition & Metabolism, 2006 Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N +7 more
doaj +3 more sources
Experimental and Therapeutic Medicine, 2021 Plant-based nutrition has become extremely popular in the contemporary era. Its positive effects are sustained by many studies, but one of its risks is that it is almost completely devoid of vitamin B12.
C. Zugravu +3 more
semanticscholar +3 more sources
Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population [PDF]
Disease Markers, 2020 Four biomarkers are commonly employed to diagnose B12 deficiency: vitamin B12 (B12), holotranscobalamin (HoloTC), methylmalonic acid (MMA), and homocysteine (Hcy).
Araceli Jarquin Campos +7 more
semanticscholar +2 more sources
Holotranscobalamin and methylmalonic acid as the diagnostic tool for vitamin B12 deficiency
Indian Journal of Dermatology, 2015 Kanica Kaushal
doaj +4 more sources
Holotranscobalamin (HoloTC, Active-B12) and Herbert’s model for the development of vitamin B12 deficiency: a review and alternative hypothesis [PDF]
SpringerPlus, 2016 The concentration of total vitamin B12 in serum is not a sufficiently sensitive or specific indicator for the reliable diagnosis of vitamin B12 deficiency.
Paul Henry Golding
semanticscholar +2 more sources
Experimental vitamin B12 deficiency in a human subject: a longitudinal investigation of the performance of the holotranscobalamin (HoloTC, Active-B12) immunoassay [PDF]
SpringerPlus, 2016 Based on Victor Herbert’s model for sequential stages in the development of vitamin B12 deficiency, the holotranscobalamin (HoloTC) immunoassay has controversially been promoted as a more specific and sensitive replacement for the total vitamin B12 test,
Paul Henry Golding
semanticscholar +2 more sources
Comparability and Stability of Holotranscobalamin levels in Capillary and Venous Blood
bioRxiv, 2023 Introduction Self-collected capillary blood has numerous advantages over venous samples taken via phlebotomy, as such the use of this finger-prick testing has increased over recent years, driven in some part by Covid antibody testing.
Woolley T, Rutter E, Staudenmaier M.
europepmc +2 more sources