The distribution of total vitamin B12, holotranscobalamin, and the active vitamin B12 fraction in the first 5 weeks postpartum [PDF]
International Journal of Laboratory Hematology, 2018 Introduction Total vitamin B12 levels decrease significantly during pregnancy and recover to normal values within 8-week postpartum. Holotranscobalamin (holoTC) reflects the active part of vitamin B12 and has been shown to remain constant during ...
V. Woude, Pijnenborg, D. Vries, Van Wijk
semanticscholar +6 more sources
Seminal but not Serum Levels of Holotranscobalamin are Altered in Morbid Obesity and Correlate with Semen Quality: A Pilot Single Centre Study [PDF]
Nutrients, 2019 Vitamin B12 (cobalamin) is an essential cofactor in the one-carbon metabolism. One-carbon metabolism is a set of complex biochemical reactions, through which methyl groups are utilised or generated, and thus plays a vital role to many cellular functions ...
J. Samavat +10 more
semanticscholar +2 more sources
Ultra-processed foods and plant-based alternatives impair nutritional quality of omnivorous and plant-forward dietary patterns in college students [PDF]
Scientific ReportsThe health benefits of a plant-based diet may be outweighed by an increased consumption of ultra-processed foods (UPF) and plant-based alternatives.
Svenja Fedde +4 more
doaj +2 more sources
Indian journal of endocrinology and metabolism, 2022 Background: Metformin use may be associated with vitamin B12 deficiency especially in vegetarians. Objectives: To determine the prevalence of holotranscobalamin deficiency among vegetarian and nonvegetarian patients with type 2 DM using metformin.
Lavanya Bonny +4 more
semanticscholar +2 more sources
Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility [PDF]
The American Journal of Clinical Nutrition, 2011 Approximately one-quarter of circulating cobalamin (vitamin B-12) binds to transcobalamin (holoTC) and is thereby available for the cells of the body. For this reason, holoTC is also referred to as active vitamin B-12. HoloTC was suggested as an optimal marker of early vitamin B-12 deficiency >20 y ago.
Ebba Nexø, Elke Hoffmann
openalex +4 more sources
Vitamin B12 and Holotranscobalamin Levels in Diabetic Peripheral Neuropathy Patients
Indian journal of Medical Biochemistry, 2016 ABSTRACT Diabetic neuropathy is the most common and debilitating microvascular complication leading to nontraumatic amputations. Identifying the role of vitamin B12 in the etiology of neuropathy is crucial because simple vitamin B12 replacement may reverse neurologic symptoms if confirmed.
Noorjahan Mohammed +3 more
openalex +2 more sources
False low holotranscobalamin levels in a patient with a novel TCN2 mutation [PDF]
Clinical Chemistry and Laboratory Medicine (CCLM), 2016 Abstract Background: Measurement of holotranscobalamin (holoTC) is increasingly used as a screening test for cobalamin (Cbl) deficiency. A level well below the reference interval strongly supports a deficient state.
P. Keller +5 more
semanticscholar +6 more sources
Active B12: A Rapid, Automated Assay for Holotranscobalamin on the Abbott AxSYM Analyzer [PDF]
Clinical Chemistry, 2008 AbstractBackground: Conventional tests for vitamin B12 deficiency measure total serum vitamin B12, whereas only that portion of vitamin B12 carried by transcobalamin (holotranscobalamin) is metabolically active. Measurement of holotranscobalamin (holoTC) may be more diagnostically accurate for detecting B12 deficiency that requires therapy.
Jeff Brady +4 more
openalex +4 more sources
Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12) [PDF]
EFSA Journal, 2015 Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12).
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)
doaj +2 more sources
Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction [PDF]
BMC MedicineBackground The role of one-carbon metabolism and related B-vitamins in cognitive function in ageing is well-documented, particularly for folate and vitamin B12, with vitamin B6 and riboflavin receiving much less attention.
Shane Gordon +13 more
doaj +2 more sources