Results 81 to 90 of about 99,018 (274)

Homeobox genes in normal and abnormal vasculogenesis [PDF]

, 2008
Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with ...
Terracciano, L., Cillo, C., Schiavo, G., Cantile, M.   +3 more
core   +2 more sources

Homeobox gene clusters.

, 2015
Homeobox gene clusters.
Lois Tang (746913), Umesh Gangishetti (746914), Martin Lüppert (746909), David L. Baillie (262780), Thomas R. Bürglin (746915), Akram M. Abou-Zied (746908), Johan Henriksson (462482), Johan Dethlefsen (746910), Yong Guang Tong (746912), Krishanu Mukherjee (746911), Jürgen Hench (194035)   +10 more
core   +1 more source

HOXA9 (homeobox A9) [PDF]

, 1998
Review on HOXA9 (homeobox A9), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Optimal activation of an endogenous gene by HOX11 requires the NH 2- terminal 50 amine acids [PDF]

, 1998
The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of acute T-cell leukemia. In addition, analysis of Hox11(-/-) mice has demonstrated a critical role for this gene in murine spleen ...
Masson, N., Greene, W.K., Rabbitts, T.H.
core  

OTX2 (orthodenticle homeobox 2) [PDF]

, 2011
Review on OTX2 (orthodenticle homeobox 2), with data on DNA, on the protein encoded, and where the gene is ...
Wortham, M, M Wortham
core   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Evolution of homeobox genes

WIREs Developmental Biology, 2012
AbstractMany homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to 14 gene classes in plants.
openaire   +2 more sources

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

HOX gene dysregulation in head and neck squamous cell carcinoma: mechanisms, clinical relevance, and future perspectives

Frontiers in Oncology
Accumulated genomic and transcriptomic evidence in head and neck squamous cell carcinoma (HNSCC) has revealed widespread molecular alterations associated with tumor initiation, progression, and therapeutic resistance.
Norma Carolina Hernandez-Bautista, Claudia Altamirano-Torres, Jose Manuel Vazquez-Guillen, Reyes S. Tamez-Guerra, Cristina Rodríguez-Padilla, Diana Resendez-Perez   +5 more
doaj   +1 more source