Results 91 to 100 of about 119,108 (236)

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

A genomic approach to the study of Tribolium castaneum genetics, development & evolution [PDF]

, 2004
During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development ...
Savard, Joël
core  

Genetic Abnormalities and Clinical Management of Fetal Genitourinary System Anomalies in Eastern China

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT To investigate the correlation between genetic abnormalities and fetal genitourinary (GU) anomalies in Eastern China and to provide assistance for the clinical management of fetuses with different types of GU anomalies. Five hundred forty‐five fetuses with GU anomalies were enrolled, undergoing karyotyping, copy number variation sequencing ...
Jie Liang, Jiebin Wu, Lin Zhang, Yunmeng Qi, Yi Wang, Xu Cao, Jingfang Zhai   +6 more
wiley   +1 more source

Timing the generation of distinct retinal cells by homeobox proteins.

PLoS Biology, 2006
The reason why different types of vertebrate nerve cells are generated in a particular sequence is still poorly understood. In the vertebrate retina, homeobox genes play a crucial role in establishing different cell identities.
Sarah Decembrini, Massimiliano Andreazzoli, Robert Vignali, Giuseppina Barsacchi, Federico Cremisi   +4 more
doaj   +1 more source

Protein evolution of ANTP and PRD homeobox genes

BMC Evolutionary Biology, 2008
Background Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes.
Holland Peter WH, Vieira Cristina P, Fonseca Nuno A, Vieira Jorge   +3 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

The use of information theory in evolutionary biology

, 2011
Information is a key concept in evolutionary biology. Information is stored in biological organism's genomes, and used to generate the organism as well as to maintain and control it. Information is also "that which evolves". When a population adapts to a
Adami, Adami, Adami, Adami, Adami, Adami, Ash, Atchley, Ay, Ay, Ay, Balduzzi, Balduzzi, Barrick, Basharin, Benner, Bialek, Billeter, Blount, Callahan, Carothers, Clarke, Cooper, Cover, da Silva, Darwin, Eddy, Edlund, Ewens, Federhen, Finn, Fletcher, Fletcher, Futuyma, Garcia-Horsman, Hartl, Iliopoulos, Jühling, Klyubin, Korber, Kryazhimskiy, Landauer, Lenski, Lenski, Lenski, Levy, Li, Linsker, Lungarella, Lungarella, Maynard Smith, McGill, Pauling, Polani, Queller, Rivoire, Robinson, Schneidman, Scott, Shannon, Sporns, Sporns, Taanman, Thornton, Tononi, Tononi, Tononi, Tononi, Tononi, Tononi, Tononi, Tononi, van der Graaff, Waddington, Wahl, Wang, Wang, Wiener, Woods, Zahedi   +79 more
core   +1 more source

Transcript profiling for early stages during embryo development in Scots pine [PDF]

, 2016
Background: Characterization of the expression and function of genes regulating embryo development in conifers is interesting from an evolutionary point of view.
Abrahamsson, Malin, Canovas, Francisco, Craven-Bartle, Blanca, Merino, Irene, Sterck, Lieven, von Arnold, Sara   +5 more
core   +2 more sources

Lhx4,a LIM Homeobox Gene

Genomics, 1997
LIM homeobox genes are well conserved in evolution and play important roles as transcriptional regulators of embryonic development. Here we report on the structure of LIM domains of the mouse Lhx4 (Gsh4) gene. The cDNA was generated by modified reverse transcription-PCR from midgestation embryo templates, using a degenerate consensus primer.
T, Yamashita, K, Moriyama, H Z, Sheng, H, Westphal   +3 more
openaire   +2 more sources

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source