Results 81 to 90 of about 119,108 (236)
Homeobox and Polycomb target gene methylation in human solid tumors
Scientific ReportsDNA methylation is an epigenetic mark that plays an important role in defining cancer phenotypes, with global hypomethylation and focal hypermethylation at CpG islands observed in tumors. These methylation marks can also be used to define tumor types and
Reid Blanchett +2 more
doaj +1 more source
Scientific Reports, 2017 Homeobox genes regulate embryonic and placental development, and are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear.
Boris Novakovic +11 more
doaj +1 more source
WIREs Developmental Biology, 2012 AbstractMany homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to 14 gene classes in plants.
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Drosophila NK-homeobox genes. [PDF]
Proceedings of the National Academy of Sciences, 1989 Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative of homeobox proteins that recognizes nucleotide sequences in DNA. The amino acid sequences of NK-2, NK-3, and NK-4 homeoboxes are more closely related to one
Y, Kim, M, Nirenberg
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Advanced Science, EarlyView.This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao +7 more
wiley +1 more source
Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype [PDF]
, 2004 The LIM homeodomain family of transcription factors is involved in many processes in the developing CNS, ranging from cell fate specification to connectivity.
Alifragis, P, Liapi, A, Parnavelas, JG
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WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement
Advanced Science, EarlyView.This review synthesizes emerging insights into WUSCHEL (WUS) as a central regulator of plant stem cell fate beyond Arabidopsis, highlighting its roles in regeneration, somatic embryogenesis (SE), and stress adaptation across crops. It explores how WUS‐centered regulatory networks, genome editing, and AI‐guided strategies can be leveraged for precise ...
Zishan Ahmad +6 more
wiley +1 more source
Bta-miR-10b secreted by bovine embryos negatively impacts preimplantation embryo quality [PDF]
, 2019 In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake results
Deforce, Dieter +6 more
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Advanced Science, EarlyView.Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]
, 2012 Peer reviewedPublisher ...
A Kubo +42 more
core +2 more sources