Results 21 to 30 of about 1,571 (154)

Allylation of Functionalized Aldehydes by Potassium Allyltrifluoroborate Catalyzed by 18-Crown-6 in Aqueous Media

Molecules, 2012
An efficient method for the allylation of aldehydes containing a broad range of functional groups using potassium allyltrifluoroborate is described.
Roberta A. Oliveira, Paulo H. Menezes, Caio F. Melo, Juliano C. R. Freitas, Fernanda C. G. Barbosa   +4 more
doaj   +1 more source

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis. [PDF]

ChemistryOpen
This review highlights synthetic advances (2013–2025) in intramolecular C─N bond formation for constructing the pharmaceutically relevant pyrrolidine core. The review is organized into five methodological clusters: 1) intramolecular alkene/alkyne amination; 2) tandem annulations, which involve C─N bond formation as the key step; 3) nucleophilic ...
Kroņkalne R, Turks M.
europepmc   +2 more sources

NbCl₅-Mg Reagent System in Regio- and Stereoselective Synthesis of (2Z)-Alkenylamines and (3Z)-Alkenylols from Substituted 2-Alkynylamines and 3-Alkynylols

Molecules, 2021
The reduction of N,N-disubstituted 2-alkynylamines and substituted 3-alkynylols using the NbCl5–Mg reagent system affords the corresponding dideuterated (2Z)-alkenylamine and (3Z)-alkenylol derivatives in high yields in a regio- and stereoselective ...
Rita N. Kadikova, Azat M. Gabdullin, Oleg S. Mozgovoj, Ilfir R. Ramazanov, Usein M. Dzhemilev   +4 more
doaj   +1 more source

Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization

Beilstein Journal of Organic Chemistry, 2010
Cycloalkanones were utilized in the Lewis acid catalyzed peroxyacetalization of ß-hydroperoxy homoallylic alcohols (prepared by the ene reaction of the allylic alcohols mesitylol and methyl 4-hydroxytiglate, respectively, with singlet oxygen) to give ...
Axel G. Griesbeck, Lars-Oliver Höinck, Jörg M. Neudörfl   +2 more
doaj   +1 more source

Asymmetric Iron‐Catalyzed Vicinal C(sp3)─H Diamination of Carboxylic Acids

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
An iron‐catalyzed vicinal α,β‐C(sp3)─H diamination of readily available carboxylic acids furnishes chiral α,β‐diamino acids in a single pot with high regio‐, diastereo‐, and enantioselectivity (up to >20:1 dr and >99% ee). ABSTRACT The direct construction of chiral 1,2‐diamines through the stereoselective functionalization of two vicinal C(sp3)─H bonds
Bing Zhou, Yuan Zheng, Xiulan Xie, Marcel Hemming, Sergei I. Ivlev, Eric Meggers   +5 more
wiley   +2 more sources

Catalytic Scalable Synthesis of Polyketides Enabled by Chiral Brønsted Acid-Catalyzed Asymmetric Allylborations. [PDF]

Chem Rec
The scalable synthesis of target molecules is crucial for applications such as biological evaluation in medicinal chemistry and even industrial production. We described recent advances in chiral Brønsted acid–catalyzed asymmetric allylboration, which enables access to previously elusive chiral building blocks, and highlight its application to the ...
Umemiya S, Terada M.
europepmc   +2 more sources

Palladium-Catalyzed Enantiospecific Three-Component Reaction for the Synthesis of 1,2,4-Trisubstituted Homoallylic Alcohols

Organics
1,2,4-Trisubstituted chiral homoallylic alcohols are valuable intermediates in natural product synthesis and complex molecular architectures; however, their catalytic asymmetric synthesis remains challenging due to the need for precise control of ...
Ayumu Natsubori, Momoka Ikeda, Yushin Hosokawa, Mizuki Akagawa, Yoshikazu Horino   +4 more
doaj   +1 more source

Use of Cyclic Allylic Bromides in the Zinc–Mediated Aqueous Barbier–Grignard Reaction

Molecules, 2001
The zinc–mediated aqueous Barbier–Grignard reaction of cyclic allylic bromide substrates with various aldehydes and ketones to afford homoallylic alcohols was investigated. Aromatic aldehydes and ketones afforded adducts in good yields (66–
Suzanne M. Perala, Brian P. Conrad, Christine A. Hughey, John H. Shugart, Gary W. Breton   +4 more
doaj   +1 more source

Cobalt-catalyzed nucleophilic addition of the allylic C(sp3)–H bond of simple alkenes to ketones

Beilstein Journal of Organic Chemistry, 2018
We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities.
Tsuyoshi Mita, Masashi Uchiyama, Kenichi Michigami, Yoshihiro Sato   +3 more
doaj   +1 more source

Three-component coupling of aryl iodides, allenes, and aldehydes catalyzed by a Co/Cr-hybrid catalyst

Beilstein Journal of Organic Chemistry, 2018
The cobalt/chromium-catalyzed three-component coupling of aryl iodides, allenes, and aldehydes has been developed to afford multi-substituted homoallylic alcohols in a diastereoselective manner.
Kimihiro Komeyama, Shunsuke Sakiyama, Kento Iwashita, Itaru Osaka, Ken Takaki   +4 more
doaj   +1 more source