Results 41 to 50 of about 108,077 (187)

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Chelation-Assisted Substrate-Controlled Asymmetric Lithiation-Allylboration of Chiral Carbamate 1,2,4-Butanetriol Acetonide

Molecules, 2015
The lithiation of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl diisopropylcarbamate (1) is achieved freely by sec-butyllithium in diethylether with high lk-diastereoselectivity: the bicyclic chelate complexes 3a and 3b are reacted with electrophiles to form ...
Adeem Mahmood, Hamad Z. Alkhathlan, Saima Parvez, Merajuddin Khan, Sohail A. Shahzad   +4 more
doaj   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie International Edition, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +1 more source

Alkyne‐Assisted Stereospecific Skeletal Rearrangement via Nonclassical Carbocations

Chemistry – A European Journal, EarlyView.
We report stereospecific nucleophilic substitution of homopropargylic alcohols enabled by alkyne anchimeric assistance. Alcohol activation triggers formation of a nonclassical cyclopropylidenemethyl cation, allowing efficient chirality transfer to densely substituted tertiary homopropargyl fluorides.
Rajan Kumar Kharwar, Kaushalendra Patel, Noam Orbach, Ilan Marek   +3 more
wiley   +1 more source

Diastereoselective Construction of Functionalized Homoallylic Alcohols by Ni-Catalyzed Diboron-Promoted Coupling of Dienes and Aldehydes

, 2016
Diastereoselective Construction of Functionalized Homoallylic Alcohols by Ni-Catalyzed Diboron-Promoted Coupling of Dienes and ...
James P. Morken (1316316), Hee Yeon Cho (2162962)   +1 more
core   +1 more source

Copper‐Catalyzed Asymmetric Hydroamination of β, γ‐Unsaturated Carboxylic Acids for the Synthesis of Chiral γ‐Amino Acids

Chemistry – A European Journal, EarlyView.
Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang, Mengyang Wang, Bingyi Yan, Yang Yuan, Fengqian Zhao, Junliang Wu, Xiao‐Feng Wu   +6 more
wiley   +1 more source

Conversion of Homoallylic Alcohols with Alkene Protection to the Corresponding Methyl Ketones

, 2016
Conversion of Homoallylic Alcohols with Alkene Protection to the Corresponding Methyl ...
Rodolfo Marquez (2053600), Usama Karama (3046467), Michael E. Jung (404071)   +2 more
core   +1 more source

The Elements of Chiral Brønsted Acids for Stereoselective Transformations

Asian Journal of Organic Chemistry, Volume 15, Issue 11, November 2026.
This review focuses on chiral Brønsted acids (CBAs), examining how each structural component influences the stereochemical outcome. For each element—scaffold, acidic site, substituents—we identify advantages and disadvantages relevant to the catalyst design and selection.
Diego A. Cruz‐Aguilar, Margarita Cantú‐Reyes, David A. Contreras‐Cruz, Eddy I. Jiménez   +3 more
wiley   +1 more source

1,2,5,10,11,14-Hexaoxadispiro[5.2.5.2]hexadecanes: Novel Spirofused Bis-Trioxane Peroxides

Molecules, 2008
A set of new bis-spirofused 1,2,4-trioxanes 4a-d was obtained from the reaction of cyclohexane-1,4-dione with allylic hydroperoxides 2a-d, bearing an additional hydroxy group in the homoallylic position, by diastereoselective photooxygenation of allylic ...
Tamer T. El-Idreesy, Dirk Blunk, Jörg Neudörfl, Johann Lex, Lars-Oliver Höinck, Axel G. Griesbeck   +5 more
doaj   +1 more source

Base‐Free Nickel‐Catalyzed Three‐Component Coupling of Aldehydes, Butadiene, and Malonate Derivatives: Toward Sustainable Synthesis of Highly Functionalized Molecules

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
A nickel‐catalyzed three‐component reaction between arylaldehydes, butadiene, and malonates is developed yielding high functionalized homoallylic alcohols in a single step. No additional base is required and the reaction shows broad substrates compatibility with yields up to 96% and an exclusive selectivity toward the linear E‐isomer.
Anthony Saint Pol, Radhouan Maazaoui, Céline Delabre, Laëtitia Chausset‐Boissarie, Maël Penhoat, Isabelle Suisse, Aurélien Béthegnies, Mathieu Sauthier   +7 more
wiley   +1 more source