Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial. [PDF]
, 2017 Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B12 , B6 , and folic acid are cofactors in homocysteine metabolism, and supplementation with B vitamins
Bauer, Douglas C +8 more
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Effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids [PDF]
, 1974 The effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids was studied and the following results were obtained.
Ikegami, T. +3 more
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Rapid healing of a patient with dramatic subacute combined degeneration of spinal cord: a case report [PDF]
, 2017 Background: Prevalence of cobalamin deficiency is high especially in older patients and an immediate therapy start is necessary to prevent irreversible neurological damages. Unfortunately, the diagnosis of cobalamin deficiency is difficult and at present,
Roessler, Florian C., Wolff, Stephanie
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Comprehensive Therapy, 2002 Homocystemia is a pathological condition that represents a significant role in cardiovascular morbidity and mortality. The epidemiology, pathophysiology, and clinical diagnostics and treatment aspects are described and discussed.
Robert, Hasty, Edward N, Smolar
openaire +4 more sources
Homocysteine and familial longevity: the Leiden Longevity Study.
PLoS ONE, 2011 Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease.
Carolien A Wijsman +9 more
doaj +1 more source
Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries [PDF]
, 2009 The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Chareyre, Corinne +6 more
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NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells
BMC Neuroscience, 2008 Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models.
Ientile Riccardo +5 more
doaj +1 more source
Importance of Raised Serum Homocysteine Levels in Ischemic Stroke Patients [PDF]
Liaquat National Journal of Primary CareBackground: Around 5.5 million people die from stroke each year, making it the second leading cause of mortality worldwide. Increased homocysteine levels lead to early neurological deteriorations in ischemic stroke and may have an association with other
Rida Batool, Syeda Nosheen Zehra
doaj +1 more source
Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells [PDF]
, 2017 Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.
Antony, Aśok C. +7 more
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Increased telomere attrition following renal transplantation: impact of anti-metabolite therapy [PDF]
, 2016 Background: The uremic milieu exposes chronic kidney disease (CKD) patients to premature ageing processes. The impact of renal replacement therapy (dialysis and renal transplantation [RTx]) or immunosuppressive treatment regimens on ageing biomarkers has
Bárány, Peter +13 more
core +1 more source