Results 41 to 50 of about 72,239 (257)

A Smart Ru‐Locked Chemiluminescence Probe via Bioorthogonal Activation for Highly Selective, Real‐Time and Noninvasive In Vivo Imaging of Thiol Dysregulation

Aggregate, EarlyView.
A smart Ru‐catalyzed chemiluminescence probe based on phenoxy‐adamantyl‐1,2‐dioxetane (PAD) scaffolds is developed for highly sensitive, real‐time in vivo imaging. Featuring a Ru‐locked activation mechanism and a chemiluminophore synthesized via an optimized route, this noninvasive probe enables selective, light‐independent detection of H₂S and thiol ...
Dongnan Guo, Dan Xu, Xiaofeng Wei, Chunying Fan, Bobo Wang, Laifu Li, Haixia Song, Wenguang Yang, Yujie Wang, Zhaojia Wang, Xiaofang Hou, Sicen Wang   +11 more
wiley   +1 more source

Homocysteine and Psychiatric Disorders [PDF]

Journal of Inborn Errors of Metabolism and Screening, 2017
Psychiatric disorders are highly prevalent all over the world with a great impact on public health. Altered homocysteine metabolism is implicated in the pathogenesis of many of these disorders, as it can interfere in normal methylation of subcellular components, promote neuroexcitotoxicity, and induce oxidative stress and inflammation.
Silva, Vanessa Cavalcante da, Oliveira, Allan Chiaratti de, D’Almeida, Vânia   +2 more
openaire   +5 more sources

The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan

BMC Cardiovascular Disorders, 2021
Background Our study aimed to determine the association between homocysteine levels and cardiovascular disease (CVD) risk in middle-aged and elderly adults in a community in northern Taiwan. Methods Participants in our study included adults aged 50 to 85 
Chin-Chuan Shih, Yu-Lin Shih, Jau-Yuan Chen   +2 more
doaj   +1 more source

Contribution of Addictovigilance data to assess adverse‐events linked to psychoactive substances in children and adolescents

British Journal of Clinical Pharmacology, EarlyView.
Aims We sought to characterize adverse events and deaths associated with the use of psychoactive substances in children and adolescents. Methods Two French Addictovigilance databases were analysed: spontaneous reports and deaths over the period 2016–2021, in subjects aged 10–<18 years. An unsupervised classification was implemented on consumption data (
Hélène Peyrière, Anne Batisse, Nathalie Fouilhé Sam‐Laï, Amélie Daveluy, Christine Fournier‐Choma, Sylvie Deheul, Cécile Chevalier, Clémence Lacroix, Valérie Gibaja, Aurélie Aquizerate, Stéphanie Pain, Emilie Jouanjus, Marie‐Christine Picot, Erika Nogue   +13 more
wiley   +1 more source

Therapeutical approach to plasma homocysteine and cardiovascular risk reduction

Therapeutics and Clinical Risk Management, 2008
Marcello Ciaccio, Giulia Bivona, Chiara BelliaDepartment of Medical Biotechnologies and Forensic Medicine, Faculty of Medicine, University of Palermo, ItalyAbstract: Homocysteine is a sulfur-containing aminoacid produced during metabolism of methionine ...
Marcello Ciaccio, Giulia Bivona, Chiara Bellia   +2 more
doaj  

Expanding the Phenotypic Spectrum of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in Childhood: A Case Series. [PDF]

Clin Case Rep
ABSTRACT Methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare inborn error of folate metabolism. A number of phenotypic findings have been identified to date, and we hereby wish to expand its phenotype based on our Irish experience of the condition.
Loftus E, Elbishari Z, Fitzsimons P, Howard C, Sheikh Y, Lynch B, Crushell E, Knerr I.   +7 more
europepmc   +2 more sources

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

ChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska, Jan Hendrik Illies, T. Moritz Weber   +2 more
wiley   +1 more source

Homocysteine and transmethylations in uremia

Kidney International, 2001
Homocysteine is regarded as a cardiovascular risk factor in both the general population and chronic renal failure patients. Among the mechanisms for homocysteine toxicity, its interference with transmethylation reactions, through its precursor/derivative S-adenosylhomocysteine, plays a multifarious role.
PERNA, Alessandra, INGROSSO, Diego, CASTALDO P, GALLETTI P, DE SANTO NG   +4 more
openaire   +4 more sources

Engineering Substrate Acceptance of Resveratrol O‐Methyltransferase from Vitis vinifera for the Selective Synthesis of O‐Methyl Protected Biobased Hydroxystyrenes

ChemCatChem, EarlyView.
Reaction sequence for the synthesis of methylated products through enzymatic decarboxylation of bio‐based hydroxycinnamic acids and subsequent direct methylation of the resulting styrene intermediates without any further isolation and purification steps.
Kamela Myrtollari, Andrea M. Chánique, Daniel Kracher, Daniela P. Herrera, Joaquin Gutierrez‐Benavente, Andreas Schüller, Robert Kourist   +6 more
wiley   +1 more source

Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Background Elevated high blood pressure is controlled by complicated, little‐understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure‐related genomic loci have been identified through previous genome‐wide association
Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny N. M. Soetedjo   +7 more
wiley   +1 more source