Results 41 to 50 of about 22,728 (180)
Alzheimer's &Dementia, EarlyView.Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri +10 more
wiley +1 more source
The role of homocysteine in endothelial dysfunction [PDF]
The Moldovan Medical Journal, 2017 Background: Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine, an essential amino acid. Hyperhomocysteinemia defines the state in which concentrations of homocysteine exceeds normal level.
Elena Visternicean
doaj +1 more source
Annals of Neurology, EarlyView.At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard +22 more
wiley +1 more source
Analysis &Sensing, EarlyView.Sensor design increasingly focusses on miniaturized systems deployed directly at the point of need. For this purpose, microfluidics ensures low‐cost systems that can handle small sample volumes and molecularly imprinted polymers provide rugged, cost‐effective recognition.
Ramya Karunakaran +4 more
wiley +1 more source
Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications
Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022 Abstract Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access.
Keshav Raj Paudel +19 more
wiley +1 more source
Therapeutical approach to plasma homocysteine and cardiovascular risk reduction
Therapeutics and Clinical Risk Management, 2008 Marcello Ciaccio, Giulia Bivona, Chiara BelliaDepartment of Medical Biotechnologies and Forensic Medicine, Faculty of Medicine, University of Palermo, ItalyAbstract: Homocysteine is a sulfur-containing aminoacid produced during metabolism of methionine ...
Marcello Ciaccio +2 more
doaj
Chemoenzymatic Total Synthesis of Lansai B
Chemistry – A European Journal, EarlyView.Lansai B was obtained in a chemoenzymatic approach from the small building block 5‐bromoindole utilizing two enzymes. Applying a tryptophan synthase and a further characterized C3‐methyltransferase the sterically demanding framework is constructed within just six steps. After late‐stage Suzuki‐coupling and n‐methylation the natural product was isolated.
Marcel Schatton +5 more
wiley +1 more source
Considerations of automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure [PDF]
Pacific Symposium on Biocomputing, 2018 (Vol. 23), 2017 With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic profiling endeavors, where ...
arxiv
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Chemistry – A European Journal, EarlyView.The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer +7 more
wiley +1 more source
Creatine: A valuable supplement in aquafeeds?
Reviews in Aquaculture, Volume 15, Issue 1, Page 292-304, January 2023., 2023 Abstract Creatine is an amino acid derivate commonly found in vertebrate muscle tissue. Creatine facilitates the recycling of adenosine triphosphate and thus contributes to the energy supply of the muscles as well as the brain. Creatine is used as a supplement for several reasons and its effects in humans, particularly in sports medicine, have been ...
Sven Wuertz, Stefan Reiser
wiley +1 more source