Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]
, 2019 Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna +6 more
core +2 more sources
Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries [PDF]
, 2009 The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Chareyre, Corinne +6 more
core +2 more sources
Increased telomere attrition following renal transplantation: impact of anti-metabolite therapy [PDF]
, 2016 Background: The uremic milieu exposes chronic kidney disease (CKD) patients to premature ageing processes. The impact of renal replacement therapy (dialysis and renal transplantation [RTx]) or immunosuppressive treatment regimens on ageing biomarkers has
Bárány, Peter +13 more
core +1 more source
Estrogen and homocysteine [PDF]
Cardiovascular Research, 2002 Cardiovascular diseases are the major causes of illness and death in women. Premenopausal women are relatively protected from coronary artery disease and atherosclerosis as compared to postmenopausal women, and this protection is attributed to the effects of the female sex hormone (estrogen). The vasculature, like the reproductive tissues, bone, liver,
Kamellia R, Dimitrova +3 more
openaire +2 more sources
Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress
PLoS ONE, 2022 Abnormally high serum homocysteine levels have been associated with several disorders, including obesity, cardiovascular diseases or neurological diseases.
Arini Isnani Preninka +8 more
doaj
Acta Biochimica et Biophysica Sinica, 2022 Although the association of elevated homocysteine level with cardiac hypertrophy has been reported, the molecular mechanisms by which homocysteine induces cardiac hypertrophy remain inadequately understood.
Sun Wentao +5 more
doaj +1 more source
Homocysteine and psoriasis [PDF]
Bioscience Reports, 2019 AbstractPsoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin
Xiran Lin, Xianmin Meng, Zhiqi Song
openaire +2 more sources
Homocysteine: A Potential Common Route for Cardiovascular Risk and DNA Methylation in Psoriasis
Chinese Medical Journal, 2017 Objective: Homocysteine is a sulfur-containing amino acid with potential clinical significance. Abnormal homocysteine levels have been found in patients with psoriasis.
Wen-Ming Wang, Hong-Zhong Jin
doaj +1 more source
Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]
, 2010 Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai +4 more
core +1 more source
Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats. [PDF]
PLoS ONE, 2013 Elevated homocysteine is an important risk factor that increases cerebrovascular and neurodegenerative disease morbidity. In mammals, B vitamin supplementation can reduce homocysteine levels.
Yijian Zhang +4 more
doaj +1 more source