Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia. [PDF]
PLoS ONE, 2012 Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations of 494 children with acute lymphoblastic leukemia treated with high-dose methotrexate in the ...
Hauke Rühs +6 more
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Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis [PDF]
, 2018 Background. The lead (Pb) exposure crisis in Flint, Michigan has passed from well-publicized event to a footnote, while its biological and social impact will linger for lifetimes.
Bayon, Baindu L. +3 more
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Monaldi Archives for Chest Disease, 2016 elevated plasma levels of homocysteine are associated with an increased risk of atherosclerosis and cardiovascular ischemic events. Despite this evidence, however, there are still concerns about the mechanisms(s) by which homocysteine exerts its pro ...
Giuseppe Caramia, Romualdo Belardinelli
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Homocysteine treatment alters redox capacity of both endothelial and tumor cells [PDF]
, 2015 Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pathways, namely, the activated methyl cycle and the linear trans-sulfuration pathway that allows the conversion of methionine to cysteine.
Cárdenas, Casimiro +5 more
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Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]
, 2014 The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa +8 more
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Neurotoxic and neuroprotective effects of homocysteine and hydrogen sulfide
Учёные записки Казанского университета: Серия Естественные науки, 2018 Homocysteine is a sulfhydryl-containing amino acid derived from methionine. The cellular concentration of homocysteine is regulated by two key pathways: remethylation back to methionine or transsulfuration to cysteine with simultaneous production of ...
G.F. Sitdikova +2 more
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Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels
Vascular Health and Risk Management, 2007 Jutta Dierkes, Claus Luley, Sabine WestphalInstitute of Clinical Chemistry and Biochemistry, University Hospital Magdeburg, Germany Abstract: Elevated plasma concentrations of homocysteine, a sulfur-containing amino acid, are a risk factor for coronary ...
Jutta Dierkes +2 more
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High paternal homocysteine causes ventricular septal defects in mouse offspring
iScienceSummary: Maternal hyperhomocysteinemia is widely considered as an independent risk of congenital heart disease (CHD). However, whether high paternal homocysteine causes CHD remains unknown.
Lian Liu +5 more
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Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect [PDF]
, 2017 No abstract ...
Baird, Susan F. +5 more
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Central European Journal of Sport Sciences and Medicine, 2014 Homocysteine is an indirect metabolite of methionine metabolism, as well as of creatinine, and it plays an important role in many biochemical processes.
Eugenia Murawska-Ciałowicz
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