Results 1 to 10 of about 3,621 (182)

Conversion of Squid Pen to Homogentisic Acid via Paenibacillus sp. TKU036 and the Antioxidant and Anti-Inflammatory Activities of Homogentisic Acid [PDF]

Marine Drugs, 2016
The culture supernatant of Paenibacillus sp. TKU036, a bacterium isolated from Taiwanese soils, showed high antioxidant activity (85%) when cultured in a squid pen powder (SPP)-containing medium at 37 °C for three days.
San-Lang Wang, Hsin-Ting Li, Li-Jie Zhang, Zhi-Hu Lin, Yao-Haur Kuo   +4 more
doaj   +2 more sources

Detection of homogentisic acid by electrospray ionization mass spectrometry. [PDF]

J Clin Lab Anal, 2023
AbstractObjectiveHomogentisic acid (HGA) is excreted in excessive amounts in the urine of patients with alkaptonuria, which is a hereditary metabolic disorder of phenylalanine and tyrosine. Therefore, the detection of HGA in urine is useful for the diagnosis of alkaptonuria.
Tokuhara Y, Ohara K, Morinishi T, Yamaguchi K, Tada S.   +4 more
europepmc   +3 more sources

Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages [PDF]

Nature Communications, 2019
The ability to image macrophages in vivo would provide insights into homeostasis and disease but current imaging agents have effects on viability and functionality.
Ina Weidenfeld, Christian Zakian, Peter Duewell, Andriy Chmyrov, Uwe Klemm, Juan Aguirre, Vasilis Ntziachristos, Andre C. Stiel   +7 more
doaj   +2 more sources

Ochronotic Arthropathy of the Shoulder – A Rare Case Report [PDF]

Journal of Orthopaedic Case Reports
Introduction: Alkaptonuria is a metabolic disorder due to accumulation of homogentisic acid, leading to destruction of major joints. Very few cases of ochronosis with shoulder involvement have been reported in literature. Case Report: We report a 31-year-
Ayyappan V Nair, Kiran V, Aravind Rajan, Bharath Bharadwaj MS, Manisha Ashwin Daware, Prince Shanavas Khan   +5 more
doaj   +2 more sources

A Yarrowia lipolytica Strain Engineered for Pyomelanin Production

Microorganisms, 2021
The yeast Yarrowia lipolytica naturally produces pyomelanin. This pigment accumulates in the extracellular environment following the autoxidation and polymerization of homogentisic acid, a metabolite derived from aromatic amino acids.
Macarena Larroude, Djamila Onésime, Olivier Rué, Jean-Marc Nicaud, Tristan Rossignol   +4 more
doaj   +1 more source

Ophthalmological Manifestations of Alkaptonuria

Oftalʹmologiâ, 2022
Alkaptonuria is rare autosomal recessive multisystem disease, caused by mutations in the homogentisine oxidase gene, which leads to the deposition of metabolites of homogentisic acid in organs and tissues (ochronosis).The purpose: to study spectrum of ...
E. V. Denisova, A. V. Kuzin
doaj   +1 more source

Complex reconstruction/ replacement of both hip and knee joints in advance stage of ochronotic arthropathy- A case report

Journal of Orthopaedic Reports, 2023
Background: Ochronotic Arthropathy is very rare disorder (around one in million people). It is due to deficiency of enzyme homogentisic acid oxidase which leads to accumulation of homogentisic acid (HGA) and causes damage of several connective tissues ...
Sanjeev Jain, Sabeel Ahmad, K. Vishwas
doaj   +1 more source

Long-term follow-up of bilateral hip and knee arthroplasty secondary to ochronotic arthropathy

Arthroplasty Today, 2020
Alkaptonuria is a rare metabolic disorder caused by the deficiency of homogentisic acid oxidase enzyme, which is responsible for eliminating homogentisic acid from the body through the renal system.
Imran Ilyas, MD, Syed Kashif, MD, Majed F. Algashiri, MD, Samar A. Rabbani, MD, Sahar S. Aldakhil, MD, Omar A. Al-Mohrej, MD   +5 more
doaj   +1 more source

Bilateral Breast Ochronosis: a Case Report

JPRAS Open, 2021
: Ochronosis is a syndrome characterized by bluish black discoloration due to the deposition of polymerized products of homogentisic acid (HGA) in the connective tissues.
Fatema A.J. AbdulKarim, Safwat M. Ibrahim, Arnold AD Hill, Nadeem Ajmal   +3 more
doaj   +1 more source

Alkaptonuria - Case report [PDF]

Anais Brasileiros de Dermatologia, 2014
Alkaptonuria, also called endogenous ochronosis, is a rare metabolic autosomal recessive disorder. It occurs by complete inhibition of homogentisic acid oxidase enzyme having its deposition in various tissues.
Fernanda Helena Craide, Juliana Salvini Barbosa Martins da Fonseca, Priscila Coelho Mariano, Natalia Monteiro Fernandez, Carlos Gustavo Carneiro de Castro, Yuri de Souza Lima Mene   +5 more
doaj   +1 more source