Homologous Pairing between Long DNA Double Helices
, 2016 Molecular recognition between two double stranded (ds) DNA with homologous sequences may not seem compatible with the B-DNA structure because the sequence information is hidden when it is used for joining the two strands.
Mazur, Alexey K.
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The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. [PDF]
, 2013 For most organisms, chromosome segregation during meiosis relies on deliberate induction of DNA double-strand breaks (DSBs) and repair of a subset of these DSBs as inter-homolog crossovers (COs).
Dernburg, Abby +6 more
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Developing single-molecule TPM experiments for direct observation of successful RecA-mediated strand exchange reaction. [PDF]
PLoS ONE, 2011 RecA recombinases play a central role in homologous recombination. Once assembled on single-stranded (ss) DNA, RecA nucleoprotein filaments mediate the pairing of homologous DNA sequences and strand exchange processes.
Hsiu-Fang Fan +2 more
doaj +1 more source
Which way up? Recognition of homologous DNA segments in parallel and antiparallel alignment
, 2014 Homologous gene shuffling between DNA promotes genetic diversity and is an important pathway for DNA repair. For this to occur, homologous genes need to find and recognize each other.
Aaron Wynveen +6 more
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The differential extension in dsDNA bound to Rad51 filaments may play important roles in homology recognition and strand exchange [PDF]
, 2014 RecA and Rad51 proteins play an important role in DNA repair and homologous recombination. For RecA, X-ray structure information and single molecule force experiments have indicated that the differential extension between the complementary strand and its
Danilowicz, Claudia +6 more
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Optimizing the design of oligonucleotides for homology directed gene targeting. [PDF]
PLoS ONE, 2011 BACKGROUND: Gene targeting depends on the ability of cells to use homologous recombination to integrate exogenous DNA into their own genome. A robust mechanistic model of homologous recombination is necessary to fully exploit gene targeting for ...
Judith Miné-Hattab +4 more
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Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments [PDF]
, 1982 Unsynchronized cells of an essentially diploid strain of female Chinese hamster cells derived from lung tissue (CHL) were laser-UV-microirradiated (=257 nm) in the nucleus either at its central part or at its periphery.
B Dutrillaux +38 more
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Somatic Pairing in Drosophila virilis Mitosis [PDF]
, 1975 In neuroblast cells homologous chromosomes tend to pair during prophase of mitosis. Heterochromatic elements of homologous chromosomes are widely separated in very early prophase, at which time the euchromatin is poorly stained.
Guest, William C.
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Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. [PDF]
PLoS Genetics, 2013 Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome, most
Andrew T Schuster +3 more
doaj +1 more source
Toward a general theory of linking invariants
, 2005 Let N_1, N_2, M be smooth manifolds with dim N_1 + dim N_2 +1 = dim M$ and let phi_i, for i=1,2, be smooth mappings of N_i to M with Im phi_1 and Im phi_2 disjoint.
Arnol’d +18 more
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