Results 41 to 50 of about 137,826 (378)
iScience, 2021 Summary: The discovery of homologous recombination deficiency (HRD) biomarkers in prostate cancer is important for patients who will benefit from poly ADP-ribose polymerase inhibitor (PARPi).
Yawei Li +11 more
doaj +1 more source
Cancers, 2023 Simple Summary In patients with epithelial ovarian cancer, the gold standard Myriad MyChoice® CDx assay is used to assess homologous recombination deficiency (HRD), as a biomarker predicting benefit from a targeted treatment, poly (ADP-ribose) polymerase
E. Fountzilas +15 more
semanticscholar +1 more source
Niraparib in ovarian cancer. results to date and clinical potential [PDF]
, 2017 Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both ...
Benedetti Panici, Pierluigi +5 more
core +1 more source
Homologous recombination deficiency: how genomic signatures are generated
Current Opinion in Genetics & Development, 2021 Cancer genomes harbor mutational and structural rearrangements that are jointly shaped by DNA damage and repair mechanisms. Accumulating evidence suggests that genetic alterations in DNA repair-defective tumors reflect the scars caused by the use of backup DNA repair mechanisms needed to maintain cellular viability. Detailed analysis of the patterns of
Jeremy, Setton +2 more
openaire +3 more sources
DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli. [PDF]
PLoS ONE, 2012 Even a partial loss of function of human RecQ helicase analogs causes adverse effects such as a cancer-prone Werner, Bloom or Rothmund-Thompson syndrome, whereas a complete RecQ deficiency in Escherichia coli is not deleterious for a cell.
Siniša Ivanković, Damir Đermić
doaj +1 more source
JCO Precision Oncology, 2023 PURPOSE Copy-number (CN) features reveal the molecular state of cancers and may have predictive and prognostic value in the treatment of cancer. We sought to apply published CN analysis methods to a large pan-cancer data set and characterize ubiquitous ...
Jay A Moore +17 more
semanticscholar +1 more source
JCO Precision Oncology, 2023 PURPOSE Poly ADP-ribose polymerase inhibitors (PARPi) are approved for patients with human epidermal growth factor receptor 2–negative metastatic breast cancer (mBC) and germline pathogenic/likely pathogenic variant (hereafter mutation) in the BRCA1/2 ...
Felipe Batalini +12 more
semanticscholar +1 more source
Homologous Recombination Repair Deficiency: An Overview for Pathologists
Modern Pathology, 2023 The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prostate cancers.
Kenneth D. Doig +2 more
openaire +3 more sources
The Utility of NGS Analysis in Homologous Recombination Deficiency Tracking
Diagnostics, 2023 Several tumor types have been efficiently treated with PARP inhibitors (PARPis), which are now approved for the treatment of ovarian, breast, prostate, and pancreatic cancers.
Aikaterini Tsantikidi +21 more
doaj +1 more source