Results 171 to 180 of about 36,553 (257)

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

Precision Radiation Oncology, EarlyView.
The study showed that TOMO‐mediated RIBE is activated by decreasing exosomal hnRNPA1 protein level and its capability to packaging miR‐27a‐3p. These new findings infer that hnRNPA1 is a novel inhibitor of RIBE, which potentiates to be a new therapeutic target for improving the efficacy of radiotherapy.
Meng‐Qi Yang, Ping Huang, Yun‐Rui Song, Yong‐Zhong Wu, Zheng Tang, Lu Zhang, Huan‐Li Luo, Yun‐Chang Liu, Dan Li, Fu Jin, Jiang‐Dong Sui, Ying Wang   +11 more
wiley   +1 more source

Enhancing tuberculosis vaccine efficacy with a heterologous mRNA-ChAdOx1 prime-pull strategy targeting lung-resident memory T cells. [PDF]

Front Immunol
Korompis M, De Voss CJ, Li S, Ateere A, McShane H, Stylianou E.   +5 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Hybrid and Vaccine-Induced Immunity Against SARS-CoV-2 in a Cohort of Hospitalized Patients from the Metropolitan Aburrá Valley, Colombia. [PDF]

Vaccines (Basel)
Hernández-Ortiz OH, Naranjo AF, Vélez-Cadavid JJ, De La Rosa G, Gil BA, Moreno AM, Perez-Restrepo LS, Usuga J, Aristizabal-Valencia M, Molina-Saldarriaga F, Sará-Ochoa JE, Betancourt-Rodriguez N, Jaimes F, Osorio JE, Hernández-Ortiz JP.   +14 more
europepmc   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Long-term kinetics of anti-RBD IgG antibodies 16 months after COVID-19 vaccination in Morocco: a longitudinal cohort study. [PDF]

Sci Rep
Abbadi I, Sarih M, Majidi H, Redwane S, Batcho S, Abounouh K, Aqillouch S, Bouddahab O, Hilmi S, Ainahi A, Tajudeen R, Fallah MP, Kaseya J, Maaroufi A, Ezzikouri S.   +14 more
europepmc   +1 more source

Evolutionary trade‐offs between beauvericin production and growth define divergent virulence strategies in Beauveria

Pest Management Science, EarlyView.
Two virulence strategies in Beauveria: a growth strategy characterized by rapid within‐host proliferation, and a toxin strategy involving antimicrobial activity and toxicity to insects Abstract BACKGROUND Pathogen virulence is often attributed to toxin production, yet toxins are metabolically costly and may not universally enhance fitness.
Shasha Hu, Lana L B de Carvalho, Ricardo A Polanczyk, Michael J Bidochka   +3 more
wiley   +1 more source

Dengue virus introduction and 2025 outlook: scenario-based evaluation of vaccination impact using mathematical modeling. [PDF]

Cad Saude Publica
Vilches TN, Ferreira CP, Telles MR, Paiz LM, Almeida GB.   +4 more
europepmc   +1 more source

From knowledge to action: the importance of characterizing herbicide resistance mechanisms for implementing management strategies

Pest Management Science, EarlyView.
This review bridges the gap between understanding resistance mechanisms and applying them in weed management, highlighting how mechanistic insights reveal vulnerabilities that can guide more effective control strategies. Abstract Herbicide resistance remains one of the most intensively studied areas in weed science because of its direct consequences ...
Luan Cutti, Eric L. Patterson, Todd A. Gaines, Aldo Merotto   +3 more
wiley   +1 more source

Comparative effectiveness of COVID-19 vaccines among health students, focusing on methodological concerns. [PDF]

Antimicrob Steward Healthc Epidemiol
Cakir B, Sertcelik A, Karadogan E, Uzar H, Temizer M, Kara SA, Ozden ME, Buzgan B, Ozyurek D, Alp A, Pinar A, Ayhan Baser D, Aksoy H, Fidanci I, Calik Basaran N, Ozyavuz Alp S, Arslan V, Sener B.   +17 more
europepmc   +1 more source