In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer [PDF]
Journal of Inflammation Research, 2021 Bashir Lawal,1,2,* Yu-Cheng Kuo,3,4,* Maryam Rachmawati Sumitra,1,2 Alexander TH Wu,5– 8 Hsu-Shan Huang1,2,8– 10 1PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University ...
Lawal B +4 more
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Hormonal signaling in the gut. [PDF]
J Biol Chem, 2014 The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a ...
Côté CD +4 more
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Dissecting the Hormonal Signaling Landscape in Castration-Resistant Prostate Cancer [PDF]
Cells, 2021 Understanding the molecular mechanisms underlying prostate cancer (PCa) progression towards its most aggressive, castration-resistant (CRPC) stage is urgently needed to improve the therapeutic options for this almost incurable pathology.
Fabrizio Fontana, Patrizia Limonta
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An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome [PDF]
Nature CommunicationsHormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time.
Shixuan Liu +13 more
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Beyond Light: Insights Into the Role of Constitutively Photomorphogenic1 in Plant Hormonal Signaling [PDF]
Frontiers in Plant Science, 2019 Light is an important environmental factor with profound effects in plant growth and development. Constitutively photomorphogenic1 (COP1) is a vital component of the light signaling pathway as a negative regulator of photomorphogenesis. Although the role
Wenjing Wang +6 more
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Multidimensional regulatory architecture of endometrial receptivity and its translational implications for implantation failure [PDF]
Frontiers in EndocrinologyEndometrial receptivity within the window of implantation (WOI) has been increasingly recognized as an independent determinant of pregnancy outcome in assisted reproduction.
Fengping Zhang +9 more
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Journal of Plant InteractionsAs an important economic crop, tobacco faces the common challenges of continuous cropping due to the limited amount of arable land. Biochar has certain preventive and control effects on continuous cropping obstacles and can improve crop yield and quality.
Yuan Ye +11 more
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Integrative systems biology analysis of barley transcriptome ─ hormonal signaling against biotic stress [PDF]
PLoS ONE, 2023 Ali Moghadam +2 more
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Phytopathogen resistance of phytohormone-deficient and low-sensitivity mutant tomatoes
Revista Ceres, 2021 This study broadens the knowledge of plant-pathogen interactions using phytohormone-deficient and low-sensitivity mutant tomatoes. The experiment was performed under greenhouse conditions and the mutants used were provided by the HCPD laboratory, at ...
Carla Dias Tunes +5 more
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Heterotrimeric G Protein Signaling in Abiotic Stress
Plants, 2022 As sessile organisms, plants exhibit extraordinary plasticity and have evolved sophisticated mechanisms to adapt and mitigate the adverse effects of environmental fluctuations. Heterotrimeric G proteins (G proteins), composed of α, β, and γ subunits, are
Yijie Wang, Jose Ramón Botella
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