Results 91 to 100 of about 1,081,032 (300)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Modulating root system architecture: cross-talk between auxin and phytohormones

Frontiers in Plant Science
Root architecture is an important agronomic trait that plays an essential role in water uptake, soil compactions, nutrient recycling, plant–microbe interactions, and hormone-mediated signaling pathways.
Mehmood Jan, Mehmood Jan, Mehmood Jan, Sajid Muhammad, Weicai Jin, Weicai Jin, Wenhao Zhong, Shaolong Zhang, Shaolong Zhang, Yanjie Lin, Yueni Zhou, Jinlong Liu, Haifeng Liu, Haifeng Liu, Raheel Munir, Qiang Yue, Muhammad Afzal, Muhammad Afzal, Muhammad Afzal, Guoping Wang, Guoping Wang   +20 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Steroid hormone signaling: multifaceted support of testicular function

Frontiers in Cell and Developmental Biology
Embryonic development and adult physiology are dependent on the action of steroid hormones. In particular, the reproductive system is reliant on hormonal signaling to promote gonadal function and to ensure fertility.
Satoko Matsuyama, Tony DeFalco, Tony DeFalco   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways

Current Issues in Molecular Biology
Endometriosis is a chronic, estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, persistent inflammation, and aberrant innervation.
Ioana-Laura Olteanu, Ciprian Pușcașu, Corina Andrei, Anca Zanfirescu   +3 more
doaj   +1 more source

“Hormonal crosstalking in the control of apical dominance in pea (Pisum sativum L.)” [PDF]

, 2013
The aim of my research is the study of the involvement of three plant growth regulators (Auxin, Gibberellins and Strigolactones) in the regulation of apical dominance in pea and how they interact to control lateral bud growth.
LUISI, ALESSANDRO
core  

Notch2 signaling in development and cancer [PDF]

, 2012
Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Signaling in deterministic and stochastic settings [PDF]

We contrast a standard deterministic signaling game with one where the signal-generating mechanism is stochastic. With stochastic signals a unique equilibrium emerges that involves separation and has intuitive comparative-static properties as the degree ...
Jeitschko, Thomas D., Normann, Hans-Theo
core