Results 131 to 140 of about 1,081,032 (300)

An Integrative Genome-Wide Analysis Reveals Shared and Subtype-Specific Genetic Links Between Endometriosis and Menstrual-Cycle-Related Traits

open access: yesInternational Journal of Women's Health
Feifei Fu,1 Feng Lin,2 Xiangjun Yao,1 Zhangbiao Xuan,1 Jialu Gu,1 Dong Shen,1 Shuqin Hu11Department of Gynecology, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, People’s Republic of China; 2Department of Urology, Affiliated ...
Fu F   +6 more
doaj  

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Melatonin: a multifaceted regulator of root development, stress responses, and hormonal crosstalk in horticultural crops

open access: yesFrontiers in Plant Science
Melatonin is increasingly recognized as a multifunctional signaling molecule involved in plant growth regulation and stress adaptation. Recent studies have revealed that melatonin plays a pivotal role in shaping root system architecture (RSA) by ...
Chenglin Liang   +5 more
doaj   +1 more source

On the emergence and evolution of artificial cell signaling networks [PDF]

open access: yes, 2007
This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
core   +2 more sources

WNT Signaling in Disease

open access: yes, 2019
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development.
Isabelle Sung   +7 more
core   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

open access: yesAdvanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao   +18 more
wiley   +1 more source

Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Collaborative Group on Hormonal Factors in Breast Cancer.

open access: yes, 1996
BACKGROUND The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide epidemiological evidence on the relation between breast cancer risk and use of hormonal contraceptives.
Collaborative Group on Hormonal Factors in Breast Cancer, Collaborative Group on Hormonal Factors in Breast
core  

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