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Signalling from parathyroid hormone
Biochemical Society Transactions, 2006PTH (parathyroid hormone), acting via type 1 PTH receptors, is a major regulator of plasma [Ca2+]. The G-protein, Gs, is an essential component of the sequence linking PTH to plasma Ca2+ regulation, but the relative importance of intracellular signals, including Ca2+ and cAMP, that lie downstream of Gs is not resolved.
S C, Tovey, S G, Dedos, C W, Taylor
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Growth Hormone-Releasing Hormone: Synthesis and Signaling
1995The molecular characterization of GHRH and the GHRH receptor provides a framework for understanding the hypothalamic regulation of pituitary somatotroph function. The signaling events discerned from our investigation of GHRH receptor structure and function form the basis of a model for GHRH action, which is shown in Fig. 20.
K E, Mayo +4 more
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Growth hormone receptor signalling
Baillière's Clinical Endocrinology and Metabolism, 1996The growth hormone (GH) receptor belongs to the superfamily of transmembrane proteins that includes the prolactin (PRL) receptor and a number of cytokine receptors. Two forms exist for the GH receptor: the membrane-bound form is a protein of 620 amino acid residues with a unique transmembrane domain; the GH-binding protein (GHBP), which is a soluble ...
M C, Postel-Vinay, P A, Kelly
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Hormone signaling in plant development
Current Opinion in Plant Biology, 2012Hormone signaling plays diverse and critical roles during plant development. In particular, hormone interactions regulate meristem function and therefore control formation of all organs in the plant. Recent advances have dissected commonalities and differences in the interaction of auxin and cytokinin in the regulation of shoot and root apical meristem
Amanda, Durbak +2 more
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Thyroid Hormone Signaling and the Liver
Hepatology, 2020Thyroid hormone (TH) plays a critical role in maintaining metabolic homeostasis throughout life. It is well known that the liver and thyroid are intimately linked, with TH playing important roles in de novo lipogenesis, beta‐oxidation (fatty acid oxidation), cholesterol metabolism, and carbohydrate metabolism.
Megan J, Ritter +2 more
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Growth-hormone signal transduction
The Journal of Pediatrics, 1997Growth hormone (GH) has long been recognized as one of the principal factors that control postnatal growth. Advances made in the last 5 years have increased our understanding of the intracellular signaling mechanisms subsequent to GH binding. The earliest event in GH signaling appears to be the binding of a single GH molecule by a pair of GH receptors (
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Growth hormone signal transduction
Experientia, 1993Growth hormone (GH) promotes animal growth by stimulating bone and cartilage cell proliferation, and influences carbohydrate and lipid metabolism. Some of these effects are brought about indirectly via somatomedin induction in hepatocytes, others by acting directly on the target cells.
P, Maharajan, V, Maharajan
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Plant hormones and nutrient signaling
Plant Molecular Biology, 2008Plants count on a wide variety of metabolic, physiological, and developmental responses to adapt their growth to variations in mineral nutrient availability. To react to such variations plants have evolved complex sensing and signaling mechanisms that allow them to monitor the external and internal concentration of each of these nutrients, both in ...
Vicente, Rubio +5 more
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Signaling mechanism of growth hormone-releasing hormone receptor
2023The hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains.
Gabor, Halmos +3 more
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Prolactin and Growth Hormone Signaling
2005Prolactin (PRL) and growth hormone (GH) act by way of their receptors as either hormones (systemically) or cytokines (locally). The Jak2/Stat5 pathway is the principal route by which PRL/GH activate target genes. The availability of knockout mice for each member of this signaling cascade has provided opportunities to understand their unique ...
Beverly S, Chilton, Aveline, Hewetson
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