Results 51 to 60 of about 1,081,032 (300)

The Arabidopsis SAL1-PAP Pathway: A Case Study for Integrating Chloroplast Retrograde, Light and Hormonal Signaling in Modulating Plant Growth and Development?

Frontiers in Plant Science, 2018
Plant growth and development are dependent on chloroplast development and function. Constitutive high level accumulation of a chloroplast stress signal, 3′-phosphoadenosine-5′-phosphate (PAP), confers drought tolerance to plants, but slow downs and ...
Su Y. Phua, Su Y. Phua, Dawei Yan, Kai X. Chan, Kai X. Chan, Gonzalo M. Estavillo, Gonzalo M. Estavillo, Eiji Nambara, Barry J. Pogson   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

TGFbeta/BMP Signaling Pathway in Cartilage Homeostasis [PDF]

, 2019
Contains fulltext : 208575.pdf (Publisher’s version ) (Open Access)Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation.
Caam, A.P.M. van, Thielen, N.G.M., Peter van der Kraan, Nathalie Thielen, Arjan van Caam, Kraan, P.M. van der   +5 more
core   +1 more source

Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

, 2021
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological ...
Wiedlocha, Antoni, Jørgen Wesche, Szybowska, Patrycja Maria, Michal Kostas, Antoni Wiedlocha, Patrycja Szybowska, Kostas, Michal Janusz, Wesche, Jørgen, Haugsten, Ellen Margrethe, Ellen Margrethe Haugsten   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Nature Communications, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show ...
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan   +18 more
doaj   +1 more source

Structural studies of Gαq signaling and regulation [PDF]

, 2008
textGαq signaling is implicated in a number of physiological processes that include platelet activation, cardiovascular development and smooth muscle function.
Shankaranarayanan, Aruna
core  

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effects of juvenile hormone in fertility and fertility-signaling in workers of the common wasp Vespula vulgaris.

PLoS ONE, 2021
In the highly eusocial wasp, Vespula vulgaris, queens produce honest signals to alert their subordinate workers of their fertility status, and therefore they are reproductively suppressed and help in the colony. The honesty of the queen signals is likely
Cintia Akemi Oi, Helena Mendes Ferreira, Rafael Carvalho da Silva, Andreas Bienstman, Fabio Santos do Nascimento, Tom Wenseleers   +5 more
doaj   +1 more source