Results 101 to 110 of about 11,515,911 (324)

Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils

Frontiers in Immunology, 2020
Polymorphonuclear neutrophils (PMN) are critical for first line innate immune defence against Staphylococcus aureus. Mature circulating PMN maintain a short half-life ending in constitutive apoptotic cell death.
Michelle E. Mulcahy, Eóin C. O’Brien, Kate M. O’Keeffe, Emilio G. Vozza, Neal Leddy, Rachel M. McLoughlin   +5 more
doaj   +1 more source

Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design

Frontiers in Cellular and Infection Microbiology, 2020
The pe/ppe genes are found in pathogenic, slow-growing Mycobacterium tuberculosis and other M. tuberculosis complex (MTBC) species. These genes are considered key factors in host-pathogen interactions. Although the function of most PE/PPE family proteins
Jianing Qian, Run-Hao Chen, Honghai Wang, Xuelian Zhang   +3 more
semanticscholar   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
McLellan, Hazel, Remco eStam, Gaëtan eThilliez, Remco Stam, Thilliez, Gaëtan, Gaëtan Thilliez, Sophie Mantelin, Hazel eMcLellan, Hazel McLellan, Stam, Remco, Mantelin, Sophie, Sophie eMantelin   +11 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

RNA-Sequencing Analyses of Small Bacterial RNAs and their Emergence as Virulence Factors in Host-Pathogen Interactions

International Journal of Molecular Sciences, 2020
Proteins have long been considered to be the most prominent factors regulating so-called invasive genes involved in host-pathogen interactions. The possible role of small non-coding RNAs (sRNAs), either intracellular, secreted or packaged in outer ...
Idrissa Diallo, P. Provost
semanticscholar   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen

Nature Communications, 2020
Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms.
Bozena Mika-Gospodorz, Suparat Giengkam, Alexander J. Westermann, J. Wongsantichon, Willow B. Kion-Crosby, Suthida Chuenklin, Loo Chien Wang, P. Sunyakumthorn, R. Sobota, S. Subbian, J. Vogel, Lars Barquist, Jeanne Salje   +12 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

The EMBO Journal
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitment at the individual organelle level are unknown ...
Di Chen, Antony Fearns, Christopher J Peddie, Maximiliano G Gutierrez   +3 more
doaj   +1 more source