Results 121 to 130 of about 11,515,911 (324)

The double-edged nature of trained immunity

eLife
Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
Chrissy M Leopold Wager, Larry S Schlesinger   +1 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Immortal genome assumption significantly underestimates replication and death rates of Mycobacterium tuberculosis in mice and monkeys

Microbiology Spectrum
Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) or against tuberculosis (TB) remain poorly defined. The ratio of colony-forming units (CFUs) to chromosomal equivalents (CEQs), [Formula: see text], recovered either ...
Allan D. Friesen, Vitaly V. Ganusov
doaj   +1 more source

Host-pathogen protein interactions predicted using structure

, 2015
<p>This dataset accompanies a manuscript describing a method to predict host-pathogen protein interactions using structure:</p> <p>Host-pathogen protein interactions predicted by comparative modeling.<br /> Davis FP, Barkan DT ...
Davis, Fred, Davis, Fred (5243422)
core   +1 more source

Evolutionary and proximate mechanisms shaping host-parasite interactions : the case of "Daphnia magna" and its natural bacterial parasite "Pasteuria ramosa" [PDF]

, 2011
Host-parasite interactions are composed of a sequence of steps, all necessary for successful infection: parasites need to encounter their hosts, to enter into their bodies, and to proliferate within them. Selection will act on the mechanisms used in each
Duneau, David
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes

Viruses, 2020
Hepatitis B virus (HBV) chronic infection is a critical risk factor for hepatocellular carcinoma. The innate immune response to HBV infection is a matter of debate. In particular, viral escape mechanisms are poorly understood.
Lise Lauterbach-Rivière, Maïwenn Bergez, Saskia Mönch, Bingqian Qu, Maximilian Riess, Florian W. R. Vondran, Juliane Liese, Veit Hornung, Stephan Urban, Renate König   +9 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Opportunities and Challenges in Studies of Host-Pathogen Interactions and Management of Verticillium dahliae in Tomatoes

, 2020
Tomatoes (Solanum lycopersicum L.) are a valuable horticultural crop that are grown and consumed worldwide. Optimal production is hindered by several factors, among which Verticillium dahliae, the cause of Verticillium wilt, is considered a major ...
Thomas W. Ingram, Bhupendra Acharya, Frank J. Louws, Ralph A. Dean, Tika B. Adhikari, YeonYee Oh   +5 more
core   +1 more source

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence [PDF]

, 2013
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and virulence, disease progression, and infection control. However, our understanding of this crucial process is still rather limited because of experimental and ...
Burton, Neil A, Mazé, Alain, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Schmidt Alexander, Burton Neil A., Farhan Hesso, Steeb Benjamin, Claudi Beatrice, Bumann Dirk, Alexander Schmidt, Hesso Farhan, Mazé Alain, Benjamin Steeb (148560), Tienz Petra, Neil A. Burton (407008), Beatrice Claudi, Alexander Schmidt (68515), Petra Tienz, Alain Mazé, Hesso Farhan (407009), Alain Mazé (126117), Neil A Burton, Claudi, Beatrice, Petra Tienz (291552), Tienz, Petra, Farhan, Hesso, Burton, Neil A., Bumann, Dirk, Benjamin Steeb, Steeb, Benjamin, Schmidt, Alexander, Schmidt A, Claudi B, Steeb B, Tienz P, Farhan H, Burton NA, Mazé A, Bumann D   +40 more
core   +2 more sources