Results 141 to 150 of about 11,515,911 (324)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host–Pathogen Interactions and Innate Immunity

International Journal of Molecular Sciences, 2019
The small GTase Arf6 has several important functions in intracellular vesicular trafficking and regulates the recycling of different types of cargo internalized via clathrin-dependent or -independent endocytosis.
T. Van Acker, J. Tavernier, F. Peelman
semanticscholar   +1 more source

Computational Systems Biology of Pathogen-Host Interactions [PDF]

, 2016
A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in initiating and sustaining infections ...
Tunahan Çakır, Reinhard Guthke, Saliha eDurmus, Tunahan eCakir, Saliha Durmuş, Cak?r, Tunahan, Çakır, Tunahan, Guthke, Reinhard, Tunahan Cak?r, Durmuş, Saliha, Reinhard eGuthke   +10 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis

Cell Death Discovery
Staphylococcus aureus is an important human commensal which persistently colonizes up to 30% of the human population, predominantly within the nasal cavity. The commensal lifestyle of S. aureus is complex, and the mechanisms underpinning colonization are
Emilio G. Vozza, Alanna M. Kelly, Clíodhna M. Daly, Sinead A. O’Rourke, Simon R. Carlile, Brenda Morris, Aisling Dunne, Rachel M. McLoughlin   +7 more
doaj   +1 more source

Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases

Molecular Systems Biology, 2017
Organisms are constantly exposed to microbial pathogens in their environments. When a pathogen meets its host, a series of intricate intracellular interactions shape the outcome of the infection.
Pierre M. Jean Beltran, Joel D. Federspiel, Xin-Lei Sheng, I. Cristea   +3 more
semanticscholar   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Resource Availability Determines Stability for Mutualist–pathogen–host Interactions

, 2015
Traditional explorations of interspecific interactions have generated extensive bodies of theory on mutualism and disease independently, but few studies have considered the interaction between them. We developed a model exploring the interactions among a
Umbanhowar, James, Rúa, Megan A.
core   +1 more source

Heterogeneous host susceptibility enhances prevalence of mixed-genotype micro-parasite infections [PDF]

, 2011
Dose response in micro-parasite infections is usually shallower than predicted by the independent action model, which assumes that each infectious unit has a probability of infection that is independent of the presence of other infectious units. Moreover,
Zwart, Mark P., Lia Hemerik, Hemerik, L., Just M. Vlak, Mark P. Zwart, Mark P Zwart, Vlak, J.M., van der Werf, Wopke, van der Werf Wopke, Hemerik, Lia, Just M Vlak, Hemerik Lia, Vlak Just M., Zwart Mark P., Zwart, M.P., Wopke van der Werf, Vlak, Just M., Werf, W., van der   +17 more
core   +2 more sources

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source