Results 151 to 160 of about 11,515,911 (324)

Long Non-coding RNAs in Host-Pathogen Interactions

Trends in immunology, 2019
Long non–coding RNAs (lncRNAs) are key molecules that regulate gene expression in a variety of organisms. LncRNAs can drive different transcriptional and post-transcriptional events that impact cellular functions.
Federica Agliano, Vijay A. K. Rathinam, A. Medvedev, S. Vanaja, A. Vella   +4 more
semanticscholar   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Tricked or trapped-Two decoy mechanisms in host-pathogen interactions. [PDF]

, 2018
Antagonistic interactions between hosts and pathogens frequently result in arms races. The host attempts to recognise the pathogen and inhibit its growth and spread, whereas the pathogen tries to subvert recognition and suppress host responses.
Renier A. L. van der Hoorn, Judith K. Paulus, Renier A L van der Hoorn, Judith K Paulus   +3 more
core   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

Host-Pathogen Interactions in Gram-Positive Bacterial Pneumonia

Clinical Microbiology Reviews, 2019
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Despite broad literature including basic and translational scientific studies, many gaps in our understanding of host-pathogen interactions remain.
Jennifer A. Grousd, Helen E. Rich, J. F. Alcorn   +2 more
semanticscholar   +1 more source

Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire [PDF]

, 2010
Background: Pythium ultimum (P. ultimum) is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results: The P.
Beakes, Gordon W, Lévesque, CA, Cano, L., Puiu, D, Ronald P De Vries, Raffaele, Sylvain, Hostetler, Jessica, Henrissat, B., Paul D Thomas, Phuntmart, Vipaporn, Boore, J.L., Brett R Whitty, Beakes, GW, Whitty, Brett R, Grenville-Briggs, L., Whitty, Brett R., Horner, N, Cano, L, Raffaele, S., Robideau, Gregg P, Steve Ferriera, Tisserat, Ned, Shetty, J, Tisserat, N., Busam, D, Krajaejun, T., Stajich, JE, Holt, C, Yandell, M, Zerillo, MM, C Robin Buell, West, Pieter van, Morris, P., Hamilton, John P, Pedro M Coutinho, Buell, C. Robin, Martin, Frank, Wawra, S, Whitty, B.R., Sucheta Tripathy, Meijer, Harold J. G., Thines, Marco, Buell, C.R., Wawra, Stephan, Win, J, Gregg P Robideau, Gordon W Beakes, Gachon, Claire M. M., Henk Brouwer, Gachon, C.M.M., Ned Tisserat, Susan I Fuerstenberg, Whitty, BR, Busam, Dana, Phuntmart, V., Thomas, P.D., Govers, F, Mark Yandell, Hostetler, J, Marcelo M Zerillo, Gachon, Claire MM, Lévesque, C.A., Neil Horner, Beakes, G.W., Tisserat, N, Dana Busam, Dumas, B., Yandell, M., Horner, Neil, Krajaejun, T, Zerillo, M.M., Joe Win, Edgar Huitema, Tyler, Brett M., Robideau, G.P., Zerillo, Marcelo M, Grenville-Briggs, L, Krajaejun, Theerapong, Raffaele, S, Vries, Ronald Peter de, Johnson, J, Theerapong Krajaejun, Coutinho, Pedro, M, Lévesque, C André, Yandell, Mark, Govers, F., Vries, R.P., de, van West, Pieter, Rays HY Jiang, Puiu, Daniela, Boore, JL, Beakes, Gordon W., De Vries, Ronald P., Coutinho, P.M., Gaulin, Elodie, Win, J., Barry Moore, van West, P, Meijer, H.J.G., Meijer, HJG, Lin, H., Wawra, S., Lin, H, Jessica Hostetler, Paul Morris, Lévesque, C. André, Stephan Wawra, Sylvain Raffaele, Laura Grenville-Briggs, Fuerstenberg, S.I., Bernard Dumas, Meijer, Harold JG, Shetty, J., Phuntmart, V, Tripathy, S, Coutinho, Pedro M., Gachon, Claire M M, Moore, B, Thines, M, Claire MM Gachon, Fuerstenberg, SI, Robideau, Gregg P., Henrissat, Bernard, Dumas, B, Huitema, Edgar; id_orcid, Brouwer, Henk, Grenville-Briggs, Laura, Moore, Barry, Hostetler, J., Huitema, E., Liliana Cano, Puiu, D., Coutinho, Pedro,, Hamilton, J.P., Ferriera, Steve, Zerillo, Marcelo M., Marco Thines, Daniela Puiu, Huitema, E, Sophien Kamoun, Henrissat, B, Boore, Jeffrey L., Jiang, Rays HY, Stajich, Jason E, De Vries, Ronald P, Bernard Henrissat, Kamoun, Sophien, Gaulin, E, Brouwer, H., Win, Joe, Gaulin, E., West, P., van, Huitema, Edgar, Brouwer, H, Justin Johnson, Jiang, Rays H. Y., Thines, M., Jyoti Shetty, Tripathy, S., Frank Martin, Tyler, Brett M, Buell, C Robin, Jiang, RHY, Buell, CR, Morris, Paul, Govers, Francine, Tyler, B.M., Jason E Stajich, Ferriera, S, Jiang, R.H.Y., John P Hamilton, Martin, F, Meijer, Harold J G, Kamoun, S., Jiang, Rays H Y, Brett M Tyler, Fürstenberg, Susan, Hamilton, John P., Lin, Haining, Horner, N., Elodie Gaulin, Thomas, Paul D, Haining Lin, Robideau, GP, Coutinho, PM, Johnson, Justin, Tyler, BM, Harold JG Meijer, Francine Govers, Fuerstenberg, Susan I, Cano, Liliana, Vipaporn Phuntmart, Stajich, J.E., Moore, B., Holt, Carson, Thomas, Paul D., Holt, C., Hamilton, JP, Gachon, CMM, Shetty, Jyoti, Stajich, Jason E., Carson Holt, Jeffrey L Boore, Coutinho, Pedro M, Martin, F., Boore, Jeffrey L, De Vries, RP, Johnson, J., Pieter van West, Morris, P, Thomas, PD, C André Lévesque, Fuerstenberg, Susan I., Dumas, Bernard, Ferriera, S., Tripathy, Sucheta, Kamoun, S, Busam, D., Meijer, Harold J., Gachon, Claire M., Jiang, Rays H., Lévesque, C. A.   +221 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Scientific Reports
In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health.
Alyssa Schami, M. Nurul Islam, Matthew Wall, Amberlee Hicks, Reagan Meredith, Barry Kreiswirth, Barun Mathema, John T. Belisle, Jordi B. Torrelles   +8 more
doaj   +1 more source

MEDNER.DE: Medicinal Product Entity Recognition in German-Specific Contexts

IEEE Access
Named entity recognition (NER) is an area of significant interest in the field of medicine, particularly for identifying specific terms such as medicinal products, medical events and diagnoses from doctors’ letters. However, training NER models in
Farnaz Zeidi, Manuela Messelhauber, Roman Christof, Xing David Wang, Ulf Leser, Dirk Mentzer, Renate Konig, Liam Childs   +7 more
doaj   +1 more source

Defining host–pathogen interactions employing an artificial intelligence workflow

eLife, 2019
For image-based infection biology, accurate unbiased quantification of host–pathogen interactions is essential, yet often performed manually or using limited enumeration employing simple image analysis algorithms based on image segmentation. Host protein
Daniel Fisch, A. Yakimovich, B. Clough, Joseph Wright, Monique Bunyan, M. Howell, J. Mercer, Eva-Maria Frickel   +7 more
semanticscholar   +1 more source