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Host defense peptides: roles and applications.
Current protein & peptide science, 2005Editorial of special issue on Antimicrobial ...
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Host‐defense peptide mimicry for novel antitumor agents
The FASEB Journal, 2009ABSTRACT ABSTRACT Although evidence is accumulating for promising anticancer properties of host‐defense peptides (HDPs), their potential therapeutic use suffers from limitations inherent to peptide pharmaceuticals, including poor bioavailability and potential toxicity.
Viktoria, Held-Kuznetsov +3 more
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Host-defense peptides: from biology to therapeutic strategies
Cellular and Molecular Life Sciences, 2011Primitive innate defense mechanisms in the form of gene-encoded antimicrobial peptides are now considered as potential candidates for the development of new therapeutics. They are well known for their function as the first protective barrier of all organisms against microbial infections.
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How bacteria resist killing by host-defense peptides
Trends in Microbiology, 1994Small cationic peptides with antimicrobial properties are part of the innate immune response of a wide variety of animal species, including insects, amphibians and mammals. Bacterial pathogens have evolved distinct mechanisms to avoid, inactivate or resist the killing effects of these peptides.
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Host defense peptides in crocodilians – A comprehensive review
PeptidesAmphibians and reptiles, like all animals, are prone to periodic infections. However, crocodilians stand out for their remarkable ability to remain generally healthy and infection-free despite frequent exposure to a wide variety of microorganisms in their habitats and often sustaining significant injuries.
Cordero Gil, Trinidad de Los Angeles +3 more
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Diversity in Host Defense Antimicrobial Peptides
2016Host defense antimicrobial peptides are part of the innate immune system of organisms in multicellular eukaryotes. Following the identification of the first insect antimicrobial peptide, cecropin, in moths in 1980 (Eur J Biochem 106(1):7–16, 1980; Nature 292(5820):246–248, 1981) and the first amphibian peptide magainin in 1987 (Proc Natl Acad Sci USA ...
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