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Antiviral Activities of Human Host Defense Peptides [PDF]
Current Medicinal Chemistry, 2020 Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs).
Gill Diamond, David C Brice
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Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action [PDF]
International Journal of Molecular Sciences, 2021 Anna Mueller +2 more
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Cationic Host Defense Peptides; Novel Antimicrobial Therapeutics Against Category A Pathogens and Emerging Infections [PDF]
Pathogens and Global Health, 2016 Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antiviral, and immunomodulatory activities. They can contribute to the rapid clearance
Lorna Proudfoot +2 more
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Host defense peptides in burns
Burns, 2004Overuse of antibiotics and failure to apply basic infection control policies and procedures have contributed to the increasing multi-drug resistance of many nosocomial pathogens. The alarming increase of multi-drug-resistant bacteria (e.g. Pseudomonas aeruginosa, methicilin-resistant Staphylococci, vancomycin-resistant Enterococci) causes infected ...
L, Steinstraesser +3 more
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Antimicrobial Peptides: Amphibian Host Defense Peptides
Current Medicinal Chemistry, 2019Antimicrobial Peptides (AMPs) are one of the most common components of the innate immune system that protect multicellular organisms against microbial invasion. The vast majority of AMPs are isolated from the frog skin. Anuran (frogs and toads) skin contains abundant AMPs that can be developed therapeutically.
Jiri, Patocka +4 more
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Cationic host defense (antimicrobial) peptides
Current Opinion in Immunology, 2006Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing in organisms from insects to plants to mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that cationic peptides ...
Kelly L, Brown, Robert E W, Hancock
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International Journal of Molecular Sciences, 2009 Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses.
Tobias Hirsch +2 more
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Host defense peptides: front-line immunomodulators
Trends in Immunology, 2014Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and ...
Sarah C, Mansour +2 more
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2009
In this chapter, the authors explains genetic, structural and functional relatives of non-fish host defense peptides in fish, and they devote a portion of this discussion to each of these topics. A great leap in understanding host defense peptides in fish came when genetic techniques replaced the previously-utilised tedious and expensive purification ...
Patrzykat, A., Hancock, R. E. W.
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In this chapter, the authors explains genetic, structural and functional relatives of non-fish host defense peptides in fish, and they devote a portion of this discussion to each of these topics. A great leap in understanding host defense peptides in fish came when genetic techniques replaced the previously-utilised tedious and expensive purification ...
Patrzykat, A., Hancock, R. E. W.
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Host defense peptides: roles and applications.
Current protein & peptide science, 2005Editorial of special issue on Antimicrobial ...
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