Results 231 to 240 of about 77,663 (255)

Host Defense Peptides in Fish

2009
In this chapter, the authors explains genetic, structural and functional relatives of non-fish host defense peptides in fish, and they devote a portion of this discussion to each of these topics. A great leap in understanding host defense peptides in fish came when genetic techniques replaced the previously-utilised tedious and expensive purification ...
Patrzykat, A., Hancock, R. E. W.
openaire   +2 more sources

Host defense peptides: front-line immunomodulators

Trends in Immunology, 2014
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and ...
Sarah C, Mansour, Olga M, Pena, Robert E W, Hancock   +2 more
openaire   +2 more sources

Antifungal Host Defense Peptides

2016
Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
openaire   +1 more source

Host defense peptides: roles and applications.

Current protein & peptide science, 2005
Editorial of special issue on Antimicrobial ...
openaire   +3 more sources

The Therapeutic Potential of Host-Defense Antimicrobial Peptides

Current Drug Targets, 2002
Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they exert their antimicrobial activity by common mechanisms ie. by membrane permeabilization. Extensive structure-function studies have been
N, Sitaram, R, Nagaraj
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Natural History of Innate Host Defense Peptides

Probiotics and Antimicrobial Proteins, 2009
Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs ...
A, Linde, B, Wachter, O P, Höner, L, Dib, C, Ross, A R, Tamayo, F, Blecha, T, Melgarejo   +7 more
openaire   +2 more sources

Potential Therapeutic Application of Host Defense Peptides

2009
Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
openaire   +2 more sources

Transcriptional Regulation of Antimicrobial Host Defense Peptides

Current Protein & Peptide Science, 2015
Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu, Amanda R, Curtis, Lakshmi T, Sunkara, Guolong, Zhang   +3 more
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Functions of Antimicrobial Peptides in Host Defense and Immunity

Current Protein & Peptide Science, 2005
Antimicrobial peptides (AMPs) are effector molecules of the innate immune system. AMPs have a broad antimicrobial spectrum and lyse microbial cells by interaction with biomembranes. Besides their direct antimicrobial function, they have multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse ...
Christoph, Beisswenger, Robert, Bals
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Host defense peptides in crocodilians – A comprehensive review

Peptides
Amphibians and reptiles, like all animals, are prone to periodic infections. However, crocodilians stand out for their remarkable ability to remain generally healthy and infection-free despite frequent exposure to a wide variety of microorganisms in their habitats and often sustaining significant injuries.
Cordero Gil, Trinidad de Los Angeles, Moleón Bersani, María Soledad, Marelli, Belkis Ester, Siroski, Pablo Ariel   +3 more
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