Results 251 to 260 of about 145,208 (274)

Bacterial resistance mechanisms against host defense peptides

Cellular and Molecular Life Sciences, 2011
Host defense peptides and proteins are important components of the innate host defense against pathogenic microorganisms. They target negatively charged bacterial surfaces and disrupt microbial cytoplasmic membranes, which ultimately leads to bacterial destruction.
Tomaz, Koprivnjak, Andreas, Peschel
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Host Defense Peptides in the Oral Cavity

2008
Publisher Summary Host defense peptides (HDPs) are important in defense of tissues throughout the human mouth. Like resident microbial populations, HDPs are diverse, species-specific, and site-specific, and they have evolved in response to selection pressures exerted by resident and pathogenic microbial populations.
Deirdre A, Devine, Celine, Cosseau
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Potential Therapeutic Application of Host Defense Peptides

2009
Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
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Porcine host defense peptides: Expanding repertoire and functions

Developmental & Comparative Immunology, 2009
Host defense peptides (HDPs) are a large group of innate immune effectors that are also termed antimicrobial peptides. Because of the rapid progress that has been made in completing several animal genomes, many HDPs have been systemically defined using bioinformatic analysis and partially characterized using reverse genomic approaches.
Yongming, Sang, Frank, Blecha
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Host defense peptides: roles and applications.

Current protein & peptide science, 2005
Editorial of special issue on Antimicrobial ...
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Host‐defense peptide mimicry for novel antitumor agents

The FASEB Journal, 2009
ABSTRACT ABSTRACT Although evidence is accumulating for promising anticancer properties of host‐defense peptides (HDPs), their potential therapeutic use suffers from limitations inherent to peptide pharmaceuticals, including poor bioavailability and potential toxicity.
Viktoria, Held-Kuznetsov, Shahar, Rotem, Yehuda G, Assaraf, Amram, Mor   +3 more
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How bacteria resist killing by host-defense peptides

Trends in Microbiology, 1994
Small cationic peptides with antimicrobial properties are part of the innate immune response of a wide variety of animal species, including insects, amphibians and mammals. Bacterial pathogens have evolved distinct mechanisms to avoid, inactivate or resist the killing effects of these peptides.
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Amphibian host defense peptides

2023
A. Anju Krishnan, A.R. Sarika, K. Santhosh Kumar, Arunan Chandravarkar   +3 more
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Host defense peptides in crocodilians – A comprehensive review

Peptides
Amphibians and reptiles, like all animals, are prone to periodic infections. However, crocodilians stand out for their remarkable ability to remain generally healthy and infection-free despite frequent exposure to a wide variety of microorganisms in their habitats and often sustaining significant injuries.
Cordero Gil, Trinidad de Los Angeles, Moleón Bersani, María Soledad, Marelli, Belkis Ester, Siroski, Pablo Ariel   +3 more
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Diversity in Host Defense Antimicrobial Peptides

2016
Host defense antimicrobial peptides are part of the innate immune system of organisms in multicellular eukaryotes. Following the identification of the first insect antimicrobial peptide, cecropin, in moths in 1980 (Eur J Biochem 106(1):7–16, 1980; Nature 292(5820):246–248, 1981) and the first amphibian peptide magainin in 1987 (Proc Natl Acad Sci USA ...
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