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Advancing host-directed therapy for tuberculosis
Nature Reviews Immunology, 2015Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive host-directed therapies have the potential to shorten tuberculosis treatment duration, prevent resistance and reduce lung injury by promoting autophagy, antimicrobial peptide production and other macrophage effector mechanisms, as well as by ...
Robert S, Wallis, Richard, Hafner
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Host-directed drug therapy for tuberculosis
Nature Chemical Biology, 2015Chemical compounds designed to enhance understanding of host-pathogen interaction together with next-generation 'smart drugs' will rationally drive the discovery of promising new host-directed targets against pathogens including Mycobacterium tuberculosis, the causative agent of tuberculosis.
Reto, Guler, Frank, Brombacher
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Host-Directed Therapies for Parasitic Diseases
Future Medicinal Chemistry, 2019Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections.
Bhawana, Singh +5 more
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Host-directed therapy of tuberculosis: what is in it for microRNA?
Expert Opinion on Therapeutic Targets, 2014Tuberculosis (TB) is a major health threat and current intervention measures are far from satisfactory. MicroRNAs (miRs) have become major targets of investigations for different diseases due to their propensity to regulate gene expression in various biological processes.
IANNACCONE, MARCO +2 more
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Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design, 2016Tuberculosis (TB) ranks alongside the human immunodeficiency virus (HIV) as cause of death due to an infectious disease. Recently, host-targeted therapies (HDT) have gained attention as a means to shorten the course of treatment of drug-sensitive TB, improve treatment outcomes of drug-resistant TB and generally improve the efficacy and preserve or ...
Madhur, Sachan +5 more
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Statins as Host-Directed Therapy for Tuberculosis
2020Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, and are commonly used for primary and secondary prevention of cardiovascular disease. In addition to lowering cholesterol, statins also have broad immunomodulatory properties, and their use has been associated with improved clinical outcomes
Noton K. Dutta, Petros C. Karakousis
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Host-Directed Therapy for AIDS
Annals of Internal Medicine, 1995R B, Stricker, B, Goldberg
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Host-Directed Therapies for Tuberculosis.
Cold Spring Harbor perspectives in medicine, 2016Host-directed therapies are a relatively new and promising approach to treatment of tuberculosis. Modulation of specific host immune pathways, including those that impact inflammation and immunopathology, can limit mycobacterial infection and pathology, both in cell culture and in animal models.
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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Journal of Visualized ExperimentsImmuno-metabolism is a pivotal determinant in the progression of leishmaniasis. Synthetic biology-based approach has garnered significant attention as a step toward therapeutic intervention targeting host-associated factors that drive leishmaniasis. Synthetic biology entails the engineering of genetic components in an orthogonal and modular manner to ...
Shweta, Khandibharad, Shailza, Singh
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