Results 211 to 220 of about 103,777 (248)

Acupuncture as a potential host-directed therapeutic strategy in neuroinfectious diseases: a neuroimmune mechanistic perspective. [PDF]

Front Med (Lausanne)
Kim YJ.
europepmc   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Host-directed immune therapies: a second front in the battle against sepsis. [PDF]

J Clin Invest
Hotchkiss RS, Monneret G.
europepmc   +1 more source

Restoring Physiological Normoxia as an Adjuvant Strategy to Improve Cancer Treatment Outcomes. [PDF]

Nat Sci Sleep
Mas Bermejo C, Mas Gómez C, Sevilla-García MA, O'Connor-Reina C, Falardo Ramos S, Alonso-Romero JL, Bravo-González LA.   +6 more
europepmc   +1 more source

Beyond antimicrobials: a host-directed precision pharmacotherapy framework for septic shock. [PDF]

Front Med (Lausanne)
Cheng XZ, Li JS, An P, Han B, Li LK, Ma KL, Zhang H.   +6 more
europepmc   +1 more source

The Shifting Paradigm of Monoclonal Antibodies in COVID-19 Management: From Early Triumphs to Viral Resistance and Future Perspectives. [PDF]

Antibodies (Basel)
Ferrara F, De Berardinis F, Scognamiglio M, Zovi A.   +3 more
europepmc   +1 more source

Towards host-directed therapies for tuberculosis [PDF]

Nature Reviews Drug Discovery, 2015
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
Alimuddin Zumla, Francine Ntoumi, Roxana Rustomjee   +2 more
exaly   +12 more sources

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Host-directed Therapy: A New Arsenal to Come

Combinatorial Chemistry & High Throughput Screening, 2021
The emergence of drug-resistant strains among the variety of pathogens worsens the situation in today’s scenario. In such a situation, a very heavy demand for developing the new antibiotics has arisen, but unfortunately, very limited success has been achieved in this arena till now.
Mradul Mohan, Debapriya Bhattacharya
openaire   +2 more sources