Results 191 to 200 of about 2,511,362 (213)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Target-Based Antiviral Drug Development Against Human Respiratory Viruses. [PDF]

Pathogens
Samrat SK, Srivastava G, Zhang R, Li Z, Li H.   +4 more
europepmc   +1 more source

Editorial: Reviews in bacteria and host. [PDF]

Front Cell Infect Microbiol
Schröttner P, Harb H.
europepmc   +1 more source

Antibody-Based Therapeutics in Autoimmune Diseases: Mechanisms, Challenges, and Future Perspectives. [PDF]

Int J Mol Sci
Mahroum N.
europepmc   +1 more source

The future directions of CAR-T Cell therapy: unlocking the potential of immunotherapy in cancer treatment. [PDF]

Front Mol Med
Justiz-Vaillant AA, Soodeen S, Arozarena-Fundora R, Akpaka PE, Unakal C.   +4 more
europepmc   +1 more source

Molecular mechanisms, pathogenesis and therapeutic advances of <i>Candida albicans</i> in oral candidiasis. [PDF]

Front Cell Infect Microbiol
Sahu BK, Debta P, Patra SK, Sahu MC, Mohanta TK, Panda SK.   +5 more
europepmc   +1 more source

Special Issue, "Viruses and Eye Diseases: Emerging Mechanisms, Host-Virus Interactions, and Future Directions". [PDF]

Viruses
Shukla D.
europepmc   +1 more source