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Disease-Causing Mechanisms and Therapeutic Targets in Infectious Diseases: Implications for Clinical Management and Public Health. [PDF]

Biomedicines
Sejersen K, Sütterlin S, Larsson AO.
europepmc   +1 more source

Towards host-directed therapies for tuberculosis [Comment]

, 2016
Zumla, A., Chakaya, J., Hoelscher,M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., Rasolofo, V., Munderi, P., Singh, N., Aklillu, E., Padayatchi, N., Macete, E., Kapata, N., Mulenga, M., Kibiki, G., Mfinanga, S., Nyirenda, T., Maboko, L., Garcia-Basteiro, A., Rakotosamimanana, N., Bates, M., Mwaba, P., Reither, K., Gagneux, S., Edwards, S., Mfinanga, E., Abdulla, S., Cardona, P.J., Russell, J.B.W., Gant, V., Noursadeghi, M., Elkington, P., Bonnet, Maryline, et al.   +34 more
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Advancing host-directed therapy for tuberculosis

Nature Reviews Immunology, 2015
Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive host-directed therapies have the potential to shorten tuberculosis treatment duration, prevent resistance and reduce lung injury by promoting autophagy, antimicrobial peptide production and other macrophage effector mechanisms, as well as by ...
Robert S, Wallis, Richard, Hafner
openaire   +4 more sources

Host-directed Therapy: A New Arsenal to Come

Combinatorial Chemistry & High Throughput Screening, 2021
The emergence of drug-resistant strains among the variety of pathogens worsens the situation in today’s scenario. In such a situation, a very heavy demand for developing the new antibiotics has arisen, but unfortunately, very limited success has been achieved in this arena till now.
Mradul Mohan, Debapriya Bhattacharya
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Host-directed drug therapy for tuberculosis

Nature Chemical Biology, 2015
Chemical compounds designed to enhance understanding of host-pathogen interaction together with next-generation 'smart drugs' will rationally drive the discovery of promising new host-directed targets against pathogens including Mycobacterium tuberculosis, the causative agent of tuberculosis.
Reto, Guler, Frank, Brombacher
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Host-Directed Therapies for Parasitic Diseases

Future Medicinal Chemistry, 2019
Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections.
Bhawana, Singh, Sanjay, Varikuti, Gregory, Halsey, Greta, Volpedo, Omar M, Hamza, Abhay R, Satoskar   +5 more
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Statins as Host-Directed Therapy for Tuberculosis

2020
Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, and are commonly used for primary and secondary prevention of cardiovascular disease. In addition to lowering cholesterol, statins also have broad immunomodulatory properties, and their use has been associated with improved clinical outcomes
Noton K. Dutta, Petros C. Karakousis
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Host-directed therapies for antimicrobial resistant respiratory tract infections

Current Opinion in Pulmonary Medicine, 2016
Antimicrobial-resistant respiratory tract infections (AMR-RTIs) are increasing, presenting important management challenges worldwide. Current management of AMR-RTI patients focuses on pathogen-directed antimicrobial treatment. Overt lung inflammation, parenchymal damage, and ineffective immune activation perpetrate increased patient morbidity and ...
Markus, Maeurer, Martin, Rao, Alimuddin, Zumla   +2 more
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Host-Directed Therapy for AIDS

Annals of Internal Medicine, 1995
R B, Stricker, B, Goldberg
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