Results 61 to 70 of about 4,368,468 (230)

Recent and New Strategies for Extensively Drug-resistant Tuberculosis

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2018
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) are very problematic clinical conditions due to the few therapeutic options and long course of treatment.
Güneş Şenol
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Targeting Drug-Sensitive and -Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and Pathology

mSphere, 2016
In view of emerging drug resistance among bacterial pathogens, including Mycobacterium tuberculosis, the development of novel therapeutic strategies is increasingly being sought.
Pallavi Chandra, R. S. Rajmani, Garima Verma, Neel Sarovar Bhavesh, Dhiraj Kumar   +4 more
doaj   +1 more source

Qualitative exploration of a client-centred, goal-directed approach to community-based occupational therapy for adults with traumatic brain injury [PDF]

, 2009
OBJECTIVES. We explored the clinical application of goal-directed therapy in community-based rehabilitation from the perspective of clients with traumatic brain injury (TBI), their significant others, and their treating occupational therapists.
Doig, Emmah, Jennifer Fleming, Cornwell, Petrea L., Cornwell, Petrea L, Petrea L. Cornwell, Emmah Doig, Kuipers, Pim, Fleming, Jennifer, Pim Kuipers   +8 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Host-directed therapy for intracellular bacterial Infections [PDF]

, 2019
Antibiotic resistance is an increasing problem in the battle against (bacterial) infectious diseases. The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) threatens to render tuberculosis (TB) untreatable. Efforts to develop novel antibiotics
Korbee, C.J.
core  

Self-Directed Learning for the 21st Century

, 2019
This book is devoted to scholarship in the field of self-directed learning in the 21st century, with specific reference to higher education. The target audience of the book includes scholars in the field of self-directed learning and higher education ...
du Toit, Adri, Johnson, David W., Lubbe, Anitia, Golightly, Aubrey, Johnson, Roger T., Olivier, Jako, van Zyl, Sukie, Bergamin, Per B., Kruger, Corné, van der Westhuizen, Christo, Goede, Roelien, Laubscher, Dorothy, Bosch, Chantelle   +12 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source