Results 61 to 70 of about 342,764 (287)

A Review and Meta-Analysis of Influenza Interactome Studies

Frontiers in Microbiology, 2022
Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases.
Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Jianzhou Cui, Jianzhou Cui, Jianzhou Cui, David Engelberg, David Engelberg, David Engelberg, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim   +12 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products

Viruses, 2021
Developing broad-spectrum antiviral drugs remains an important issue as viral infections continue to threaten public health. Host-directed therapy is a method that focuses on potential targets in host cells or the body, instead of viral proteins.
Mengxun Zhang, Jiaqing Zhong, Yongai Xiong, Xun Song, Chenyang Li, Zhendan He   +5 more
doaj   +1 more source

Thoracic duct drainage before and after cadaveric kidney transplantation [PDF]

, 1979
Twenty-seven consecutive recipients of cadaveric kidneys, including five with pre-existing warm cytotoxic antibodies, were treated with thoracic duct drainage before and after transplantation.
Iwaki, Y, Koep, LJ, Schröter, GP, Starzl, TE, Terasaki, PI, Weil, R   +5 more
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Eukaryotic translation initiation machinery can operate in a prokaryotic-like mode without eIF2 [PDF]

, 2008
Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary complex eIF2*GTP*Met-tRNAiMet is utilized to deliver the initiator tRNA to the ribosome within all eukaryotic cells1.
Dmitri Andreev, Ilya Terenin, Ivan N. Shatsky, Sergey Dmitriev   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. [PDF]

, 2016
We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice.
Brombacher, F., Guler, R., Hartley, M.A., Hurdayal, R., Parihar, S.P.   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Current status of intestinal transplantation in children [PDF]

, 1998
Purpose: A clinical trial of intestinal transplantation (Itx) under tacrolimus and prednisone immunosuppression was initiated in June 1990 in children with irreversible intestinal failure and who were dependent on total parenteral nutrition (TPN ...
Asfar, Billingham, Casavilla, Deltz, Edward M Barksdale, Fontes, Furukawa, Garau, Goulet, Grant, Grant, Grant, Green, Hiro Furukawa, Iwaki, Javier Bueno, John J Fung, Jorge Reyes, Kareem Abu-Elmagd, Kashiwagi, Langnas, Lee, Lillehei, Manez, Margreiter, McAlister, Mike Green, Monchik, Murase, Murase, Porter, Putnam, Randhawa, Rao, Reyes, Reyes, Reyes, Samuel Kocoshis, Satoru Todo, Sharon Strom, Sigurdsson, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Thomas E Starzl, Todo, Tzakis, White, William Irish   +52 more
core   +1 more source