Frontiers in Cellular and Infection Microbiology, 2021 Mycobacterium tuberculosis (Mtb) causes chronic granulomatous lung disease in humans. Recently, novel strategies such as host-directed therapeutics and adjunctive therapies that enhance the effect of existing antibiotics have emerged to better control ...
Ji-Hae Park +4 more
doaj +1 more source
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis [PDF]
, 2016 Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M.
Dodoo, E, Maeurer, M, Rao, M, Zumla, A
core +1 more source
Pancreas and islet cell transplantation [PDF]
, 2002 Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation.
A.N. Balamurugan +94 more
core +1 more source
Bazedoxifene Suppresses Intracellular
mSphere, 2020 Tuberculosis (TB) is still the leading killer caused by Mycobacterium tuberculosis infection. There is a clear need for new treatment strategy against TB.
Qi Ouyang +5 more
doaj +1 more source
Genome editing technologies to fight infectious diseases [PDF]
, 2017 Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa +2 more
core +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2019 Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics.
M. Shamim Hasan Zahid +6 more
doaj +1 more source
Can We Harness Immune Responses to Improve Drug Treatment in Leishmaniasis?
Microorganisms, 2020 Leishmaniasis is a vector-borne parasitic disease that has been neglected in priority for control and eradication of malaria, tuberculosis, and HIV/AIDS.
Raphael Taiwo Aruleba +3 more
doaj +1 more source
Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria [PDF]
, 2016 Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact.
Good, L, Kamaruzzaman, N F, Kendall, S L
core +1 more source
The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]
, 2019 Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core +2 more sources
Metformin Increases Cell Viability and Regulates Pro-Inflammatory Response to Mtb
Infection and Drug Resistance, 2023 Nikita Naicker,1 Hylton Rodel,2 Rubeshan Perumal,1 Yashica Ganga,2 Mallory Bernstein,2 Ntombi Benede,2 Salim Abdool Karim,1,3 Nesri Padayacthi,1,3 Alex Sigal,2,4,5 Kogieleum Naidoo1,3 1Centre for the AIDS Programme of Research in South Africa (CAPRISA ...
Naicker N +9 more
doaj