Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis. [PDF]
BBA AdvVecchione MB +8 more
europepmc +3 more sources
Towards host-directed therapies for tuberculosis [PDF]
Nature Reviews Drug Discovery, 2015 Alimuddin Zumla +64 more
openalex +3 more sources
mTORC1 inhibitors rapamycin and everolimus as host-directed therapy for tuberculosis [PDF]
Infection and ImmunityRobin H. G. A. van den Biggelaar +1 more
doaj +2 more sources
Repurposing Antifungals for Host-Directed Antiviral Therapy?
Pharmaceuticals, 2022 Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that ...
Sebastian Schloer +2 more
doaj +1 more source
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Disease Models & Mechanisms, 2021 Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing
Kamlesh Bhatt +6 more
doaj +1 more source
Statins: a viable candidate for host-directed therapy against infectious diseases [PDF]
Nature Reviews Immunology, 2018 Suraj P. Parihar +2 more
openalex +3 more sources
Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs
Frontiers in Medicine, 2022 Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage.
Juan M. Cubillos-Angulo +30 more
doaj +1 more source
P-1383. Proapoptotic Bcl-2 Inhibitors as Adjunctive Host-Directed Therapy Enhance Tuberculosis Treatments and Long-term Cure in a Murine Model [PDF]
Open Forum Infect DisMantej Singh +6 more
europepmc +3 more sources
Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions
Microorganisms, 2020 Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals.
Ana C. Moreira +2 more
doaj +1 more source
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +5 more sources