Results 11 to 20 of about 124,225 (196)

Nanomaterial-mediated host directed therapy of tuberculosis by manipulating macrophage autophagy [PDF]

Journal of Nanobiotechnology
Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a major public health issue worldwide. Mtb has developed complicated strategies to inhibit the immunological clearance of host cells, which significantly promote TB ...
Yilin Liu, Jiajun Wang, Jiayi Yang, Jiaojiao Xia, Jiaqi Yu, Dongsheng Chen, Yuhe Huang, Fen Yang, Yongdui Ruan, Jun-Fa Xu, Jiang Pi   +10 more
doaj   +2 more sources

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis [PDF]

Nature Communications
Mycobacterium tuberculosis establishes within host cells by inducing anti-apoptotic Bcl-2 family proteins, triggering necrosis, inflammation, and fibrosis.
Medha Singh, Mona O. Sarhan, Nerketa N. L. Damiba, Alok K. Singh, Andres Villabona-Rueda, Oscar J. Nino-Meza, Xueyi Chen, Yuderleys Masias-Leon, Carlos E. Ruiz-Gonzalez, Alvaro A. Ordonez, Franco R. D’Alessio, Eric O. Aboagye, Laurence S. Carroll, Sanjay K. Jain   +13 more
doaj   +2 more sources

Metformin as Host-Directed Therapy for TB Treatment: Scoping Review [PDF]

Frontiers in Microbiology, 2020
Tuberculosis (TB) disease is an international health concern caused by the bacteria Mycobacterium tuberculosis (Mtb). Evolution of multi-drug-resistant strains may cause bacterial persistence, rendering existing antibiotics ineffective.
Nikita Naicker, Alex Sigal, Alex Sigal, Alex Sigal, Kogieleum Naidoo, Kogieleum Naidoo   +5 more
doaj   +2 more sources

Autophagy: A new strategy for host-directed therapy of tuberculosis

Virulence, 2019
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide.
Seungwha Paik, Jin Kyung Kim, Chaeuk Chung, Eun-Kyeong Jo   +3 more
doaj   +2 more sources

Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection [PDF]

Frontiers in Immunology, 2021
Despite the available antibiotics, tuberculosis (TB) has made its return since the 90’s of the last century as a global threat mostly due to co-infection with HIV, to the emergence of drug resistant strains and the lack of an effective vaccine.
David Pires, Sofia Valente, Marta Calado, Manoj Mandal, José Miguel Azevedo-Pereira, Elsa Anes   +5 more
doaj   +2 more sources

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming, Hayden T. Pacl, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn   +4 more
doaj   +2 more sources

Host-directed therapy in diabetes and tuberculosis comorbidity toward global tuberculosis elimination

International Journal of Infectious Diseases
Host-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection.
Steven G. Smith, Ruth Bowness, Jacqueline M. Cliff   +2 more
doaj   +3 more sources

Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles [PDF]

International Journal of Pharmaceutics, 2022
Nicole Remaliah Samantha Sibuyi, Patrick H Demana, Yahya E Choonara   +2 more
exaly   +2 more sources

mTORC1 inhibitors rapamycin and everolimus as host-directed therapy for tuberculosis [PDF]

Infection and Immunity
Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff   +1 more
doaj   +2 more sources

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis [PDF]

Frontiers in Immunology
Chiara Farroni, Tonino Alonzi, Emanuele Nicastri   +2 more
exaly   +2 more sources