Host-directed therapy, an untapped opportunity for antimalarial intervention [PDF]
Cell Reports Medicine, 2021 Summary: Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases caused by viruses and intracellular bacteria, but its implementation in the context of parasitic diseases has received less attention. Here, we provide a
Ling Wei +6 more
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Host-directed therapy for tuberculosis [PDF]
European Journal of Medical ResearchCurrent TB treatment regimens are hindered by drug resistance, numerous adverse effects, and long treatment durations, highlighting the need for ‘me-better’ treatment regimens. Host-directed therapy (HDT) has gained recognition as a promising approach in
Na Tian +6 more
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Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus [PDF]
Frontiers in Immunology, 2023 Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (MTB) and is one of the principal reasons for mortality and morbidity worldwide.
Li Zhao +7 more
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The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy [PDF]
eLife, 2023 A prolonged therapy, primarily responsible for development of drug resistance by Mycobacterium tuberculosis (Mtb), obligates any new TB regimen to not only reduce treatment duration but also escape pathogen resistance mechanisms.
Deepthi Shankaran +5 more
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Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism [PDF]
Frontiers in Immunology, 2020 Mycobacterium tuberculosis (Mtb) has complex and intricate interactions with host immune cells. Mtb can survive, persist, and grow within macrophages and thereby circumvent detection by the innate immune system.
Jae-Sung Kim +5 more
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Host-directed therapy for bacterial infections -Modulation of the phagolysosome pathway- [PDF]
Frontiers in Immunology, 2023 Bacterial infections still impose a significant burden on humanity, even though antimicrobial agents have long since been developed. In addition to individual severe infections, the f fatality rate of sepsis remains high, and the threat of antimicrobial ...
Toshihiko Taya +3 more
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Modulation of innate immunity in airway epithelium for host-directed therapy [PDF]
Frontiers in Immunology, 2023 Innate immunity of the mucosal surfaces provides the first-line defense from invading pathogens and pollutants conferring protection from the external environment. Innate immune system of the airway epithelium consists of several components including the
Iwona T. Myszor +2 more
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Proposing Bromo-Epi-Androsterone for Host-Directed Therapy Against Tuberculosis [PDF]
PathogensBromoepiandrosterone (BEA), a synthetic analog of the adrenal steroid DHEA, holds promise as a host-directed therapy for both active and latent tuberculosis (TB).
Coad Thomas Dow, Liam Obaid
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Host Directed Therapy Against Infection by Boosting Innate Immunity [PDF]
Frontiers in Immunology, 2020 The innate immune system constitutes the first line of defense against invading pathogens, regulating the normal microbiota and contributes to homeostasis. Today we have obtained detailed knowledge on receptors, signaling pathways, and effector molecules
Peter Bergman +6 more
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Nanomaterial-mediated host directed therapy of tuberculosis by manipulating macrophage autophagy [PDF]
Journal of NanobiotechnologyTuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a major public health issue worldwide. Mtb has developed complicated strategies to inhibit the immunological clearance of host cells, which significantly promote TB ...
Yilin Liu +10 more
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