Results 21 to 30 of about 342,764 (287)

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis [PDF]

Nature Communications
Mycobacterium tuberculosis establishes within host cells by inducing anti-apoptotic Bcl-2 family proteins, triggering necrosis, inflammation, and fibrosis.
Medha Singh, Mona O. Sarhan, Nerketa N. L. Damiba, Alok K. Singh, Andres Villabona-Rueda, Oscar J. Nino-Meza, Xueyi Chen, Yuderleys Masias-Leon, Carlos E. Ruiz-Gonzalez, Alvaro A. Ordonez, Franco R. D’Alessio, Eric O. Aboagye, Laurence S. Carroll, Sanjay K. Jain   +13 more
doaj   +2 more sources

Metformin as Host-Directed Therapy for TB Treatment: Scoping Review [PDF]

Frontiers in Microbiology, 2020
Tuberculosis (TB) disease is an international health concern caused by the bacteria Mycobacterium tuberculosis (Mtb). Evolution of multi-drug-resistant strains may cause bacterial persistence, rendering existing antibiotics ineffective.
Nikita Naicker, Alex Sigal, Alex Sigal, Alex Sigal, Kogieleum Naidoo, Kogieleum Naidoo   +5 more
doaj   +2 more sources

Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection [PDF]

Frontiers in Immunology, 2021
Despite the available antibiotics, tuberculosis (TB) has made its return since the 90’s of the last century as a global threat mostly due to co-infection with HIV, to the emergence of drug resistant strains and the lack of an effective vaccine.
David Pires, Sofia Valente, Marta Calado, Manoj Mandal, José Miguel Azevedo-Pereira, Elsa Anes   +5 more
doaj   +2 more sources

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming, Hayden T. Pacl, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn   +4 more
doaj   +2 more sources

Evaluation of Myeloperoxidase as Target for Host-Directed Therapy in Tuberculosis In Vivo. [PDF]

Int J Mol Sci, 2022
Linnemann LC, Schaible UE, Dallenga TK.
europepmc   +3 more sources

Quantitative Systems Pharmacology Modeling Framework of Autophagy in Tuberculosis: Application to Adjunctive Metformin Host-Directed Therapy. [PDF]

Antimicrob Agents Chemother, 2022
Mehta K, Guo T, Wallis RS, van der Graaf PH, van Hasselt JGC.   +4 more
europepmc   +3 more sources

Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2. [PDF]

J Virus Erad, 2022
Wali L, Karbiener M, Chou S, Kovtunyk V, Adonyi A, Gösler I, Contreras X, Stoeva D, Blaas D, Stöckl J, Kreil TR, Gualdoni GA, Gorki AD.   +12 more
europepmc   +2 more sources

Autophagy: A new strategy for host-directed therapy of tuberculosis

Virulence, 2019
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide.
Seungwha Paik, Jin Kyung Kim, Chaeuk Chung, Eun-Kyeong Jo   +3 more
doaj   +2 more sources

Arginine as host directed therapy in tuberculosis: insights from modulating arginine metabolism by supplementation and arginase inhibition. [PDF]

One Health Adv
Jiang Q, Kumar R, Zhao Y, Subbian S, Shi L.   +4 more
europepmc   +3 more sources

N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant <i>Mycobacterium abscessus</i>. [PDF]

Pathogens
Yang S, Zhang Y, Xu J, Chen Z, Ren Y, Long Y, Huang X, Liu J, Huang H, Xie S, Ma R, Dong Y, Fan X, Hu Z, Li F.   +14 more
europepmc   +3 more sources