Results 21 to 30 of about 124,225 (196)
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Disease Models & Mechanisms, 2021 Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing
Kamlesh Bhatt +6 more
doaj +1 more source
Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs
Frontiers in Medicine, 2022 Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage.
Juan M. Cubillos-Angulo +30 more
doaj +1 more source
Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions
Microorganisms, 2020 Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals.
Ana C. Moreira +2 more
doaj +1 more source
Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis
EBioMedicine, 2015 The global tuberculosis (TB) epidemic and the spread of multi- and extensively-drug resistant strains of Mycobacterium tuberculosis (M.tb) have been fueled by low adherence to following lengthy treatment protocols, and the rapid spread of HIV (Human ...
Mamoudou Maiga +7 more
doaj +1 more source
Modulating Iron for Metabolic Support of TB Host Defense
Frontiers in Immunology, 2018 Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an urgent need for novel therapies ...
James J. Phelan +5 more
doaj +1 more source
Natriuretic peptide-directed medical therapy: a systematic review
Perioperative Medicine, 2020 Natriuretic peptides (NP) are strongly associated with perioperative cardiovascular events. However, in patients with raised NP, it remains unknown whether treatment to reduce NP levels prior to surgery results in better perioperative outcomes.
Christella S. Alphonsus +3 more
doaj +1 more source
Host-directed therapies for multidrug resistant tuberculosis
International Journal of Mycobacteriology, 2016 Tuberculosis (TB) causes 1.3 million deaths annually. There are 0.5 million cases of multidrug resistant TB (MDR-TB) and the number of cases is rising globally.
Alimuddin Zumla, Markus Maeurer
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Mycobacterium tuberculosis (Mtb) causes chronic granulomatous lung disease in humans. Recently, novel strategies such as host-directed therapeutics and adjunctive therapies that enhance the effect of existing antibiotics have emerged to better control ...
Ji-Hae Park +4 more
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2019 Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics.
M. Shamim Hasan Zahid +6 more
doaj +1 more source
Bazedoxifene Suppresses Intracellular
mSphere, 2020 Tuberculosis (TB) is still the leading killer caused by Mycobacterium tuberculosis infection. There is a clear need for new treatment strategy against TB.
Qi Ouyang +5 more
doaj +1 more source