HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis
Scientific Reports, 2018 Inflammation, although responsible for controlling infection, is often associated with the pathogenesis of chronic diseases. Leishmania donovani, the causative agent of visceral leishmaniasis, induces a strong inflammatory response that leads to ...
Akil Hammami +3 more
doaj +1 more source
Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite
Molecular Systems Biology, 2020 Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role.
Jessica M Bryant +8 more
doaj +1 more source
Multiple drug resistance in hookworms infecting greyhound dogs in the USA
International Journal for Parasitology: Drugs and Drug Resistance, 2021 Ancylostoma caninum is the most prevalent nematode parasite of dogs. We confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the USA.
Pablo D. Jimenez Castro +9 more
doaj +1 more source
Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
mBio, 2011 Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
doaj +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2020 (300 words): A lack of quantitative information on the species composition of parasite communities present in fecal samples is a major limiting factor for the sensitivity, accuracy and interpretation of the diagnostic tests commonly used to assess ...
Camila Queiroz +8 more
doaj +1 more source
Benefits of host genetic diversity for resistance to infection depend on parasite diversity [PDF]
, 2010 Host populations with high genetic diversity are predicted to have lower levels of infection prevalence. This theory assumes that host genetic diversity results in variation in susceptibility and that parasites exhibit variation in infectivity. Empirical
Ebert, D., Ganz, H.
core +1 more source
Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]
, 2016 Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri +31 more
core +3 more sources
Intravital imaging of host–parasite interactions in skin and adipose tissues
Cellular Microbiology, 2019 Intravital microscopy allows the visualisation of how pathogens interact with host cells and tissues in living animals in real time. This method has enabled key advances in our understanding of host–parasite interactions under physiological conditions. A
Mariana De Niz +6 more
semanticscholar +1 more source
Toxoplasma effectors targeting host signaling and transcription [PDF]
, 2017 Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during
Ajioka JA +23 more
core +2 more sources
Lipid Droplet, a Key Player in Host-Parasite Interactions
Frontiers in Immunology, 2018 Lipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated
A. Vallochi +4 more
semanticscholar +1 more source