Results 251 to 260 of about 181,738 (289)
Some of the next articles are maybe not open access.
Antifungal Host Defense Peptides
2016Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
openaire +1 more source
Transcriptional Regulation of Antimicrobial Host Defense Peptides
Current Protein & Peptide Science, 2015Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu +3 more
openaire +2 more sources
Bacterial resistance mechanisms against host defense peptides
Cellular and Molecular Life Sciences, 2011Host defense peptides and proteins are important components of the innate host defense against pathogenic microorganisms. They target negatively charged bacterial surfaces and disrupt microbial cytoplasmic membranes, which ultimately leads to bacterial destruction.
Tomaz, Koprivnjak, Andreas, Peschel
openaire +2 more sources
Host Defense Peptides in the Oral Cavity
2008Publisher Summary Host defense peptides (HDPs) are important in defense of tissues throughout the human mouth. Like resident microbial populations, HDPs are diverse, species-specific, and site-specific, and they have evolved in response to selection pressures exerted by resident and pathogenic microbial populations.
Deirdre A, Devine, Celine, Cosseau
openaire +2 more sources
Potential Therapeutic Application of Host Defense Peptides
2009Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
openaire +2 more sources
Porcine host defense peptides: Expanding repertoire and functions
Developmental & Comparative Immunology, 2009Host defense peptides (HDPs) are a large group of innate immune effectors that are also termed antimicrobial peptides. Because of the rapid progress that has been made in completing several animal genomes, many HDPs have been systemically defined using bioinformatic analysis and partially characterized using reverse genomic approaches.
Yongming, Sang, Frank, Blecha
openaire +2 more sources
Host defense peptides: roles and applications.
Current protein & peptide science, 2005Editorial of special issue on Antimicrobial ...
openaire +3 more sources
Host‐defense peptide mimicry for novel antitumor agents
The FASEB Journal, 2009ABSTRACT ABSTRACT Although evidence is accumulating for promising anticancer properties of host‐defense peptides (HDPs), their potential therapeutic use suffers from limitations inherent to peptide pharmaceuticals, including poor bioavailability and potential toxicity.
Viktoria, Held-Kuznetsov +3 more
openaire +2 more sources
Host-defense peptides: from biology to therapeutic strategies
Cellular and Molecular Life Sciences, 2011Primitive innate defense mechanisms in the form of gene-encoded antimicrobial peptides are now considered as potential candidates for the development of new therapeutics. They are well known for their function as the first protective barrier of all organisms against microbial infections.
openaire +2 more sources
How bacteria resist killing by host-defense peptides
Trends in Microbiology, 1994Small cationic peptides with antimicrobial properties are part of the innate immune response of a wide variety of animal species, including insects, amphibians and mammals. Bacterial pathogens have evolved distinct mechanisms to avoid, inactivate or resist the killing effects of these peptides.
openaire +2 more sources