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Antifungal Host Defense Peptides

2016
Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
openaire   +1 more source

Natural History of Innate Host Defense Peptides

Probiotics and Antimicrobial Proteins, 2009
Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs ...
A, Linde   +7 more
openaire   +2 more sources

Functions of Antimicrobial Peptides in Host Defense and Immunity

Current Protein & Peptide Science, 2005
Antimicrobial peptides (AMPs) are effector molecules of the innate immune system. AMPs have a broad antimicrobial spectrum and lyse microbial cells by interaction with biomembranes. Besides their direct antimicrobial function, they have multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse ...
Christoph, Beisswenger, Robert, Bals
openaire   +2 more sources

Potential Therapeutic Application of Host Defense Peptides

2009
Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
openaire   +2 more sources

Transcriptional Regulation of Antimicrobial Host Defense Peptides

Current Protein & Peptide Science, 2015
Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu   +3 more
openaire   +2 more sources

Host defense peptides in crocodilians – A comprehensive review

Peptides
Amphibians and reptiles, like all animals, are prone to periodic infections. However, crocodilians stand out for their remarkable ability to remain generally healthy and infection-free despite frequent exposure to a wide variety of microorganisms in their habitats and often sustaining significant injuries.
Cordero Gil, Trinidad de Los Angeles   +3 more
openaire   +3 more sources

Host Defense Peptides and the Eicosanoid Cascade

2016
Host defense peptides (HDPs) and eicosanoids are two important families in host defense and inflammation. Most of the naturally occurring HDPs are cationic and amphipathic short polypeptides with typical length between 15 and 40 amino acid residues. HDPs not only possess potent antimicrobial activity against a variety of pathogens, they are also widely
Min Wan   +2 more
openaire   +1 more source

Amphibian host defense peptides

2023
A. Anju Krishnan   +3 more
openaire   +1 more source

Host Defense Peptide-Mimicking β-Peptide Polymer Displaying Strong Antibacterial Activity Against Cariogenic Streptococcus mutans

Journal of Materials Science and Technology, 2023
Mingxing Zhang, Runhui Liu, Yuxin Qian
exaly  

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