Results 241 to 250 of about 145,208 (274)
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Developmental and Comparative Immunology, 2013
Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms.
Albert van Dijk, Henk P Haagsman
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Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms.
Albert van Dijk, Henk P Haagsman
exaly +5 more sources
Antimicrobial Peptides: Amphibian Host Defense Peptides
Current Medicinal Chemistry, 2019Antimicrobial Peptides (AMPs) are one of the most common components of the innate immune system that protect multicellular organisms against microbial invasion. The vast majority of AMPs are isolated from the frog skin. Anuran (frogs and toads) skin contains abundant AMPs that can be developed therapeutically.
Jiri, Patocka +4 more
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Cationic host defense (antimicrobial) peptides
Current Opinion in Immunology, 2006Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing in organisms from insects to plants to mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that cationic peptides ...
Kelly L, Brown, Robert E W, Hancock
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Host defense peptides in burns
Burns, 2004Overuse of antibiotics and failure to apply basic infection control policies and procedures have contributed to the increasing multi-drug resistance of many nosocomial pathogens. The alarming increase of multi-drug-resistant bacteria (e.g. Pseudomonas aeruginosa, methicilin-resistant Staphylococci, vancomycin-resistant Enterococci) causes infected ...
L, Steinstraesser +3 more
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Host defense peptides: front-line immunomodulators
Trends in Immunology, 2014Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and ...
Sarah C, Mansour +2 more
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Host defense peptides and their antimicrobial-immunomodulatory duality
Immunobiology, 2011 Host defence peptides (HDPs) are short cationic molecules produced by the immune systems of most multicellular organisms and play a central role as effector molecules of innate immunity. Host defence peptides have a wide range of biological activities from direct killing of invading pathogens to modulation of immunity and other biological responses of ...
Sammy Al-Benna
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Host-defense peptides: from biology to therapeutic strategies
Cellular and Molecular Life Sciences, 2011Primitive innate defense mechanisms in the form of gene-encoded antimicrobial peptides are now considered as potential candidates for the development of new therapeutics. They are well known for their function as the first protective barrier of all organisms against microbial infections.
Maria Luisa Mangoni
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Natural History of Innate Host Defense Peptides
Probiotics and Antimicrobial Proteins, 2009Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs ...
A, Linde +7 more
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Antifungal Host Defense Peptides
2016Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
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Transcriptional Regulation of Antimicrobial Host Defense Peptides
Current Protein & Peptide Science, 2015Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu +3 more
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