Results 1 to 10 of about 814 (67)
Functions of Cationic Host Defense Peptides in Immunity
Pharmaceuticals, 2016 Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar +2 more
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Pharmaceutics, 2021 Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce bacterial-drug resistance.
Hashem Etayash, Robert E. W. Hancock
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Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications
Pharmaceuticals, 2014 Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomoduatory properties. Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and therefore,
Guolong Zhang, Lakshmi T. Sunkara
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Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis
Brazilian Journal of Oral Sciences, 2021 Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated
Ingrid Aquino Amorim +6 more
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Journal of Animal Science and Biotechnology, 2022 Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect hosts by modulating their immune responses ...
Di Wu +3 more
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Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides
mSphere, 2021 Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high potential
Melanie D. Balhuizen +5 more
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Frontiers in Immunology, 2020 Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp ...
Graham A. D. Blyth +3 more
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Proteolysis of human thrombin generates novel host defense peptides. [PDF]
PLoS Pathogens, 2010 The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot.
Praveen Papareddy +7 more
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Molecules, 2023 Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic ...
Caroline Donaghy +4 more
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The future of recombinant host defense peptides
Microbial Cell Factories, 2022 The antimicrobial resistance crisis calls for the discovery and production of new antimicrobials. Host defense peptides (HDPs) are small proteins with potent antibacterial and immunomodulatory activities that are attractive for translational applications,
Ramon Roca-Pinilla +3 more
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