Results 11 to 20 of about 2,543,243 (267)

Toward the Discovery of Host-Defense Peptides in Plants [PDF]

Frontiers in Immunology, 2020
Defense peptides protect multicellular eukaryotes from infections. In biomedical sciences, a dominant conceptual framework refers to defense peptides as host-defense peptides (HDPs), which are bifunctional peptides with both direct antimicrobial and ...
Benjamin Petre
doaj   +8 more sources

Bacterial-Specific Aggregation and Killing of Immunomodulatory Host Defense Peptides [PDF]

Pharmaceuticals, 2021
This study involves the design and development of disulfide bridge-linked antimicrobial peptides using the host defense protein Angiogenin 4 (chAng4) as a template.
Nauman Nazeer, Juan Carlos Rodriguez-Lecompte, Marya Ahmed   +2 more
doaj   +2 more sources

Host defense peptides in malaria infection: their contributions, significance and constraints [PDF]

Malaria Journal
Plasmodium-induced malaria infection remains a leading global health threat. Host defense peptides (HDPs), key components of innate immunity, target multiple stages of Plasmodium development through direct antimicrobial activity and immunomodulation ...
Dia Aldeen Alfaki, Mohamed Mubarak Elbasheir   +1 more
doaj   +2 more sources

Host Defense Peptides in Wound Healing

Molecular Medicine, 2008
Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune response in infection and inflammation. These features make them of high interest for wound healing
Lars, Steinstraesser, Till, Koehler, Frank, Jacobsen, Adrien, Daigeler, Ole, Goertz, Stefan, Langer, Marco, Kesting, Hans, Steinau, Elof, Eriksson, Tobias, Hirsch   +9 more
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Avian host defense peptides

Developmental & Comparative Immunology, 2013
Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms.
Cuperus, Tryntsje, Coorens, M., van Dijk, A., Haagsman, H.P.   +3 more
openaire   +5 more sources

Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. [PDF]

PLoS ONE, 2012
Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance and current lack of other effective treatments there is an
Martina Kalle, Praveen Papareddy, Gopinath Kasetty, Matthias Mörgelin, Mariena J A van der Plas, Victoria Rydengård, Martin Malmsten, Barbara Albiger, Artur Schmidtchen   +8 more
doaj   +3 more sources

Retro-inversion imparts antimycobacterial specificity to host defense peptides [PDF]

Nature Communications
Antimicrobial host defense peptides are promising alternatives to resistance prone small molecule antibiotics. To overcome the poor physiologic stability of these therapeutic candidates it is common to prepare proteolytically resistant retro-inverso ...
Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Diptomit Biswas, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina   +8 more
doaj   +2 more sources

Immunomodulatory Activities of Small Host Defense Peptides [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACT Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene ...
Bowdish, Dawn M E, Davidson, Donald J, Scott, Monisha G, Hancock, Robert E W   +3 more
openaire   +4 more sources

Host Defense Peptides from Asian Frogs as Potential Clinical Therapies

Antibiotics, 2015
Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological ...
Vineeth T.V. Kumar, David Holthausen, Joshy Jacob, Sanil George   +3 more
doaj   +2 more sources

Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance [PDF]

Frontiers in Microbiology, 2020
Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory processes has ...
Morgan A. Alford, Beverlie Baquir, Felix L. Santana, Felix L. Santana, Evan F. Haney, Robert E. W. Hancock   +5 more
doaj   +2 more sources