Results 11 to 20 of about 77,663 (255)
Functions of Cationic Host Defense Peptides in Immunity [PDF]
Pharmaceuticals, 2016 Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution ...
Mahadevappa Hemshekhar +2 more
doaj +6 more sources
Host Defense Peptides as Templates for Antifungal Drug Development [PDF]
Journal of Fungi, 2020 Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs: azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago.
Virginia Basso +3 more
doaj +3 more sources
Host Defense Peptides from Asian Frogs as Potential Clinical Therapies
Antibiotics, 2015 Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological ...
Vineeth T.V. Kumar +3 more
doaj +4 more sources
Strategies in Translating the Therapeutic Potentials of Host Defense Peptides [PDF]
Frontiers in Immunology, 2020 The golden era of antibiotics, heralded by the discovery of penicillin, has long been challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides (HDPs), previously known as antimicrobial peptides, are emerging as a group of ...
Darren Shu Jeng Ting +7 more
doaj +4 more sources
Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action [PDF]
International Journal of Molecular Sciences, 2021 The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due ...
Julia P Deisinger +2 more
exaly +3 more sources
Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis
Brazilian Journal of Oral Sciences, 2021 Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated
Ingrid Aquino Amorim +6 more
doaj +3 more sources
Proteolysis of human thrombin generates novel host defense peptides. [PDF]
PLoS Pathogens, 2010 The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot.
Praveen Papareddy +7 more
doaj +3 more sources
Optimizing Antimicrobial Host Defense Peptides
Chemistry & Biology, 2006 Antimicrobial host defense peptides constitute a major component of innate immune systems. Expectations are high to develop them into a novel class of anti-infective agents. In this issue of Chemistry & Biology, Hilpert et al. describe new design and peptide synthesis strategies for systematically investigating such concepts.
Hans Georg Sahl, Sahl, Hans Georg
openaire +3 more sources
Antiviral Activities of Human Host Defense Peptides [PDF]
Current Medicinal Chemistry, 2020 Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely ...
David C Brice, Gill Diamond
exaly +4 more sources
Frontiers in Microbiology, 2013 Lipopolysaccharides (LPS) are the major molecular component of the outer membrane of Gram-negative bacteria. This molecule is recognized as a sign of bacterial infection, responsible for the development of local inflammatory response and, in extreme ...
Carlos eLopez-Abarrategui +4 more
doaj +2 more sources