Results 31 to 40 of about 77,663 (255)
Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance [PDF]
Frontiers in Microbiology, 2020 Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory processes has ...
Morgan A. Alford +5 more
doaj +2 more sources
A Diverse Family of Host-Defense Peptides (Piscidins) Exhibit Specialized Anti-Bacterial and Anti-Protozoal Activities in Fishes. [PDF]
PLoS ONE, 2016 Conventional antibiotics and other chemical-based drugs are currently one of the most common methods used to control disease-related mortality in animal agriculture.
Scott A Salger +3 more
doaj +2 more sources
Expression and Function of Host Defense Peptides at Inflammation Sites. [PDF]
Int J Mol Sci, 2019 There is a growing interest in the complex role of host defense peptides (HDPs) in the pathophysiology of several immune-mediated inflammatory diseases. The physicochemical properties and selective interaction of HDPs with various receptors define their immunomodulatory effects. However, it is quite challenging to understand their function because some
Prasad SV +4 more
europepmc +6 more sources
Avian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications
Pharmaceuticals, 2014 Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomoduatory properties. Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and therefore,
Guolong Zhang, Lakshmi T. Sunkara
doaj +3 more sources
Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications [PDF]
Frontiers in Microbiology, 2011 In the last few years, the number of bacteria with enhanced resistance to conventional antibiotics has dramatically increased. Most of such bacteria belong to regular microbial flora, becoming a real challenge, especially for immune-depressed patients ...
Osmar Nascimento Silva +7 more
doaj +2 more sources
The Antimicrobial and Host Defense Peptides of Drosophila melanogaster
Annual Review of MicrobiologyDrosophila fruit flies are a powerful model for studying innate immunity. In Drosophila , seven classical antimicrobial peptide (AMP) gene families were identified in the 1990s. These genes are primarily regulated by the TOLL and IMD NF-κB pathways in response to infection.
Mark A, Hanson +3 more
openaire +4 more sources
Molecules, 2023 Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic ...
Caroline Donaghy +4 more
doaj +1 more source
Antimicrobial peptides in echinoderm host defense [PDF]
Developmental & Comparative Immunology, 2015 Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins:
Li, Chun +3 more
openaire +3 more sources
Microbiology Spectrum, 2022 Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 The burgeoning menace of antimicrobial resistance across the globe has necessitated investigations into other chemotherapeutic strategies to combat infections.
Sukriyo Chakraborty +2 more
doaj +1 more source