Results 31 to 40 of about 2,543,243 (267)

Oncolytic Activities of Host Defense Peptides [PDF]

International Journal of Molecular Sciences, 2011
Cancer continues to be a leading source of morbidity and mortality worldwide in spite of progress in oncolytic therapies. In addition, the incidence of cancers affecting the breast, kidney, prostate and skin among others continue to rise. Chemotherapeutic drugs are widely used in cancer treatment but have the serious drawback of nonspecific toxicity ...
Benna, Sammy al-, Shai, Yechiel (Prof.), Jacobsen, Frank (Dr. med.), Steinsträßer, Lars (Prof. Dr. med.)   +3 more
openaire   +3 more sources

Antimicrobial peptides in echinoderm host defense [PDF]

Developmental & Comparative Immunology, 2015
Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins:
Li, Chun, Blencke, Hans-Matti, Haug, Tor, Stensvåg, Klara   +3 more
openaire   +3 more sources

Reassessing the Host Defense Peptide Landscape [PDF]

Frontiers in Chemistry, 2019
Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicrobial peptides (AMPs) these additional roles have prompted a shift in terminology to use the broader term host ...
Evan F. Haney, Suzana K. Straus, Robert E. W. Hancock   +2 more
openaire   +3 more sources

A Diverse Family of Host-Defense Peptides (Piscidins) Exhibit Specialized Anti-Bacterial and Anti-Protozoal Activities in Fishes. [PDF]

PLoS ONE, 2016
Conventional antibiotics and other chemical-based drugs are currently one of the most common methods used to control disease-related mortality in animal agriculture.
Scott A Salger, Katherine R Cassady, Benjamin J Reading, Edward J Noga   +3 more
doaj   +1 more source

Antiviral potential of cathelicidins [PDF]

, 2014
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow.
Davidson, Donald J, Barlow, Peter G, Gwyer Findlay, Emily, Findlay, Emily Gwyer, Currie, Silke M, Davidson, D.J., Barlow, Peter G., Findlay, E.G., Currie, S.M.   +8 more
core   +1 more source

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Schöllmann, C., Korting, Hans Christian, Schäfer-Korting, Monika, Stauss-Grabo, M.   +3 more
core   +1 more source

LPS inmobilization on porous and non-porous supports as an approach for the isolation of anti-LPS host-defense peptides.

Frontiers in Microbiology, 2013
Lipopolysaccharides (LPS) are the major molecular component of the outer membrane of Gram-negative bacteria. This molecule is recognized as a sign of bacterial infection, responsible for the development of local inflammatory response and, in extreme ...
Carlos eLopez-Abarrategui, Alberto eMartinez, Osvaldo eReyes-Acosta, Octavio Luiz Franco, Anselmo Jesús Otero-González   +4 more
doaj   +1 more source

The Host Defense Proteome of Human and Bovine Milk [PDF]

, 2011
Milk is the single source of nutrients for the newborn mammal. The composition of milk of different mammals has been adapted during evolution of the species to fulfill the needs of the offspring.
Hooijdonk, A.C.M., van, Jacques Vervoort, Boeren, S., Hein van Valenberg, Vervoort Jacques, van Valenberg Hein, Sacco de Vries, de Vries Sacco, Boeren Sjef, Hettinga Kasper, Vries, S.C., de, Valenberg, H.J.F., van, Hettinga, K.A., van Hooijdonk Toon, Kasper Hettinga, Sjef Boeren, Arendonk, J.A.M., van, Toon van Hooijdonk, Johan van Arendonk, van Arendonk Johan, Vervoort, J.J.M.   +20 more
core   +2 more sources

Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria

Microbiology Spectrum, 2022
Klebsiella pneumoniae produces a thick capsule layer composed of extracellular polysaccharides protecting the bacterial cells from clearance by innate host immunity during infection.
Renee M. Fleeman, Bryan W. Davies
doaj   +1 more source

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production

Veterinary Research, 2018
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and ...
Albert van Dijk, Chris J. Hedegaard, Henk P. Haagsman, Peter M. H. Heegaard   +3 more
doaj   +1 more source