MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]
, 2017 The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D +11 more
core +3 more sources
Dietary Nutrients Mediate Intestinal Host Defense Peptide Expression [PDF]
Advances in Nutrition, 2020 The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient digestion and absorption, and microbial survival. The gut in animals faces continuous challenges in communicating with the external environment. Threats from endogenous imbalance and exogenous feeds, especially pathogens, could trigger a disorder of ...
Jianmin Wu +3 more
openaire +2 more sources
Amphibian chytridiomycosis : a review with focus on fungus-host interactions [PDF]
, 2015 Amphibian declines and extinctions are emblematic for the current sixth mass extinction event. Infectious drivers of these declines include the recently emerged fungal pathogens Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans ...
Haesebrouck, Freddy +3 more
core +4 more sources
The distribution of lectins across the phylum Nematoda : a genome-wide search [PDF]
, 2017 Nematodes are a very diverse phylum that has adapted to nearly every ecosystem. They have developed specialized lifestyles, dividing the phylum into free-living, animal, and plant parasitic species. Their sheer abundance in numbers and presence in nearly
Bauters, Lander +2 more
core +3 more sources
Optimizing Antimicrobial Host Defense Peptides
Chemistry & Biology, 2006 Antimicrobial host defense peptides constitute a major component of innate immune systems. Expectations are high to develop them into a novel class of anti-infective agents. In this issue of Chemistry & Biology, Hilpert et al. describe new design and peptide synthesis strategies for systematically investigating such concepts.
openaire +2 more sources
Serum proteomics of active tuberculosis patients and contacts reveals unique processes activated during Mycobacterium tuberculosis infection. [PDF]
, 2020 Tuberculosis (TB) is the most lethal infection among infectious diseases. The specific aim of this study was to establish panels of serum protein biomarkers representative of active TB patients and their household contacts who were either infected (LTBI)
Anibarro, L +11 more
core +2 more sources
Multifunctional host defense peptides: intracellular‐targeting antimicrobial peptides [PDF]
The FEBS Journal, 2009 There is widespread acceptance that cationic antimicrobial peptides, apart from their membrane‐permeabilizing/disrupting properties, also operate through interactions with intracellular targets, or disruption of key cellular processes. Examples of intracellular activity include inhibition of DNA and protein synthesis, inhibition of chaperone‐assisted ...
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Snake Venom Cathelicidins as Natural Antimicrobial Peptides
Frontiers in Pharmacology, 2019 Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide.
Elizângela de Barros +14 more
doaj +1 more source
Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]
, 2017 Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín +1 more
core +1 more source