Results 61 to 70 of about 145,208 (274)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity.

PLoS ONE, 2014
Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity ...
Wei Huang, Jiwon Seo, Stephen B Willingham, Ann M Czyzewski, Mark L Gonzalgo, Irving L Weissman, Annelise E Barron   +6 more
doaj   +1 more source

Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections [PDF]

, 2013
Copyright: © 2013 Baron et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
A Baeza Garcia, A Balakrishnan, ACA Hope, AJ Phillips, AN Miller, B Altincicek, B Gryseels, BC Krasity, Benjamin Gourbal, Benoit Industri, BM Tyler, C Capodici, C Hetru, CD Bingle, Christine Coustau, CP Marquis, D Hasselquist, D Pimentel, E Galiana, ER Haine, F Barbault, F Guillou, F Guillou, G Bai, G Canny, G Mitta, GW Beakes, Géraldine Dubreuil, H Gardsvoll, H Gazzano-Santoro, H Melida, H Nielsen, H Schultz, HS Judelson, J Jaenike, J Schultz, J Weiss, J Weiss, J Zweigner, JA Hoffmann, Jean-Marc Reichhart, JF Sanchez, JJ Hathaway, JM Romansic, K Benkendorff, LJ Beamer, LJ Beamer, LJ Dishaw, M Berney, M Gonzalez, MA Larkin, Matty Knight, MF Flajnik, Michel Ponchet, MJ Fenton, MN Marra, N Lamping, N Takamatsu, NS Tan, NW Schroder, Olga Lucia Baron, P Elsbach, P Elsbach, P Swain, P van West, P van West, Pieter van West, RR Schumann, S Fraune, S Kamoun, S Limmer, S Tauszig, SF Altschul, ST Mukai, TM Chucri, Y Liang   +75 more
core   +8 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. [PDF]

PLoS ONE, 2012
Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance and current lack of other effective treatments there is an
Martina Kalle, Praveen Papareddy, Gopinath Kasetty, Matthias Mörgelin, Mariena J A van der Plas, Victoria Rydengård, Martin Malmsten, Barbara Albiger, Artur Schmidtchen   +8 more
doaj   +1 more source

Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics. [PDF]

, 2019
Endovascular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major health care concern, especially infective endocarditis (IE).
Abdelhady, Wessam, Bayer, Arnold S, Chambers, Henry F, Ersoy, Selvi C, Li, Liang, Xiong, Yan Q   +5 more
core  

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa

Antibiotics, 2014
The mucosa and overlying fluid of the female reproductive tract (FRT) are portals for the heterosexual transmission of HIV-1. Toward the ongoing development of topically applied microbicides and mucosal vaccines against HIV-1, it is evermore important to
Amy Liese Cole, Alexander M. Cole
doaj   +1 more source