Results 71 to 80 of about 2,543,243 (267)

Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics

Animal Nutrition, 2018
Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention. However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all ...
Kelsy Robinson, Xi Ma, Yulan Liu, Shiyan Qiao, Yongqing Hou, Guolong Zhang   +5 more
doaj   +1 more source

Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?

Frontiers in Immunology, 2012
Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and
Sophie eCotton, Sheila eDonnelly, Mark W. Robinson, Mark W. Robinson, John P. Dalton, Karine eThivierge, Karine eThivierge   +6 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Sap transporter mediated import and subsequent degradation of antimicrobial peptides in Haemophilus. [PDF]

PLoS Pathogens, 2011
Antimicrobial peptides (AMPs) contribute to host innate immune defense and are a critical component to control bacterial infection. Nontypeable Haemophilus influenzae (NTHI) is a commensal inhabitant of the human nasopharyngeal mucosa, yet is commonly ...
Catherine L Shelton, Forrest K Raffel, Wandy L Beatty, Sara M Johnson, Kevin M Mason   +4 more
doaj   +1 more source

Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons. [PDF]

, 2020
BackgroundHost defense peptides are a family of endogenous short peptides that are found in all living beings and play a critical role in innate immunity against infection.MethodsA nonsystematic review of host defense peptides was conducted with specific
Cederna, Paul S, Da Lio, Andrew L, Deming, Timothy J, DeLong, Michael R, Tandon, Vickram J, Michael R. DeLong, Andrew L. Da Lio, Paul S. Cederna, Timothy J. Deming, Vickram J. Tandon   +9 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs

Molecules, 2018
Host-defense peptides, also called antimicrobial peptides (AMPs), whose protective action has been used by animals for millions of years, fulfill many requirements of the pharmaceutical industry, such as: (1) broad spectrum of activity; (2) unlike ...
Alicia Boto, Jose Manuel Pérez de la Lastra, Concepción C. González   +2 more
doaj   +1 more source

Dynamic Physicochemical Gradients for Tendon–Bone Regeneration

Advanced Functional Materials, EarlyView.
Dynamic physicochemical gradients offer a framework for reconnecting soft tendon and hard bone. This Review examines how hydration, transport, loading and degradation reshape these gradients during healing. Coordinating regional biological cues with progressive transfer of load from scaffold to tissue guides the design of interfaces that retain ...
Wanxue Wang, Minsheng Zhu, Junmiao Liu, Haowen Lu, Haoteng Wang, Yu Chen, Hua Liu, Zhengyu Xu, Zhiyong Sun, Huilin Yang, Yusen Qiao, Xia Zhao   +11 more
wiley   +1 more source

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria

Frontiers in Immunology, 2017
Host-defense peptides play a fundamental role in the innate immune system by modulating inflammatory responses. Previously, it was shown that the thrombin derived host-defense peptide GKY25 inhibits LPS-induced responses of monocytes and macrophages in ...
Finja C. Hansen, Ann-Charlotte Strömdahl, Matthias Mörgelin, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Mariena J. A. van der Plas   +6 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source