Results 91 to 100 of about 2,543,243 (267)

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Host-defense antimicrobial peptides: importance of structure for activity

, 2002
Antimicrobial peptides are important components of innate immunity in species across the evolutionary scale. Unlike therapeutically used antibiotics, this class of peptides exert their activity by permeabilizing bacterial membranes. Despite the seemingly
Narasimhaiah, Sitaram, Ramakrishnan, Nagaraj   +1 more
core   +1 more source

Genotoxic and cytotoxic activity of host defense peptides against human soft tissue sarcoma in an model

, 2011
Steinstraesser L, Hauk J, Al-Benna S, et al. Genotoxic and cytotoxic activity of host defense peptides against human soft tissue sarcoma in an model. Drug and Chemical Toxicology.
Becerikli, Mustafa, Sudhoff, Holger ; https://orcid.org/, Stefan Langer, Holger Sudhoff, Langer, Stefan, Lars Steinstraesser, Ring, Andrej, Frank Jacobsen, Sammy Al-Benna, Al-Benna, Sammy, Jacobsen, Frank, Marco Kesting, Andrej Ring, Hauk, Jennifer, Mustafa Becerikli, Käfferlein, Heiko, Heiko Käfferlein, Kesting, Marco, Steinstraesser, Lars, Jennifer Hauk   +19 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Host defense peptides: An insight into the antimicrobial world

Journal of Oral and Maxillofacial Pathology, 2018
A serious challenge to antimicrobial therapies has emerged due to rapid increase in drug-resistant infections creating an urge for the development of alternative therapeutics. Antimicrobial peptides (AMPs) have gained importance because of their broad-spectrum antimicrobial activities and mediator-like functions linking innate and adaptive immune ...
Gupta, Shiva, Bhatia, Gouri, Sharma, Anamika, Saxena, Sameer   +3 more
openaire   +3 more sources

Cathelicidins—Therapeutic antimicrobial and antitumor host defense peptides for oral diseases

Japanese Dental Science Review, 2011
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. Several types of host defense peptides (HDPs), including defensins, cathelicidins, and histatins, may have important roles in innate host defense.
Kazuhiko Okumura
doaj   +1 more source

Potential of immunomodulatory host defense peptides as novel anti-infectives

, 2009
A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation.
Hancock, REW, Mayer, ML, Easton, DM, Nijnik, A, Robert E.W. Hancock, Matthew L. Mayer, Donna M. Easton, Anastasia Nijnik   +7 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Snake Venom Cathelicidins as Natural Antimicrobial Peptides

Frontiers in Pharmacology, 2019
Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide.
Elizângela de Barros, Elizângela de Barros, Regina M. Gonçalves, Regina M. Gonçalves, Marlon H. Cardoso, Marlon H. Cardoso, Nuno C. Santos, Nuno C. Santos, Nuno C. Santos, Octávio L. Franco, Octávio L. Franco, Octávio L. Franco, Elizabete S. Cândido, Elizabete S. Cândido, Elizabete S. Cândido   +14 more
doaj   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source