Results 81 to 90 of about 2,543,243 (267)

Helminthic host defense peptides: using the parasite to defend the host

, 2023
: Parasitic helminths are destined to share niches with a variety of microbiota that inevitably influence their interaction with the host. To modulate the microbiome for their benefit and defend against pathogenic isolates, helminths have developed host ...
Roncevic T., Tossi A., Mladineo I., Gerdol M., Tomislav Rončević, Alessandro Tossi, Ivona Mladineo, Marco Gerdol   +7 more
core   +2 more sources

Multifunctional host defense peptides: antiparasitic activities [PDF]

The FEBS Journal, 2009
Whereas significant knowledge is accumulating on the antibacterial and antifungal properties of host defense peptides (HDPs) and their synthetic mimics, much less is known of their activities against parasites. A variety of in vitro and in vivo antiparasitic assays suggest that these notorious antimicrobial compounds could represent a powerful tool for
openaire   +2 more sources

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Host defense peptides at the crossroad of endothelial cell physiology : Insight into mechanistic and pharmacological implications

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and ...
Yadav, Vikas,, Joshi, Hemant,, Yadav, Kiran,, Garg, Vivek Kumar,, Lund University., Sharma, Amarish Kumar,, Garg, Vivek Kumar, Yadav, Vikas, Sharma, Amarish Kumar, Joshi, Hemant, Yadav, Kiran   +10 more
core   +1 more source

Anti-antimicrobial Peptides FOLDING-MEDIATED HOST DEFENSE ANTAGONISTS:FOLDING-MEDIATED HOST DEFENSE ANTAGONISTS [PDF]

, 2013
Antimicrobial or host defense peptides are innate immune regulators found in all multicellular organisms. Many of them fold into membrane-bound α-helices and function by causing cell wall disruption in microorganisms.
Judge, Peter J., Su, Bo, Martyna, Glenn, Ryan, L, Su, B, Jenkinson, Howard F., Martyna, G, Lamarre, Baptiste, Ravi, Jascindra, Temple, A, Temple, Adam, Carr, Matthew, Carr, M, Crain, Jason, Jenkinson, HF, Cerasoli, E, Ryadnov, MG, Ravi, J, Judge, PJ, Ryan, Lloyd, Lamarre, B, Watts, A, Crain, J, Diu, Ting, Watts, Anthony, Diu, T, Cerasoli, Eleonora, Ryadnov, Maxim G.   +27 more
core   +1 more source

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

Host-Defense Peptides with Therapeutic Potential from Skin Secretions of Frogs from the Family Pipidae

Pharmaceuticals, 2014
Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian ...
J. Michael Conlon, Milena Mechkarska
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

eLife
Amyloid-forming peptides are increasingly recognized as dynamic regulators at the host–pathogen interface, yet how environmental factors control their assembly and activity remains poorly understood.
Bader Rayan, Eilon Barnea, Rinat Indig, Christian F Pantoja, Jesse Gayk, Yael Lupu-Haber, Alexander Upcher, Amir Argoetti, Jacob Aunstrup Larsen, Alexander Kai Buell, Markus Zweckstetter, Meytal Landau   +11 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source