Results 81 to 90 of about 145,208 (274)
Regulation of Host Defense Peptide Synthesis by Polyphenols
Antibiotics, 2023 The rise of antimicrobial resistance has created an urgent need for antibiotic-alternative strategies for disease control and prevention. Host defense peptides (HDPs), which have both antimicrobial and immunomodulatory properties, are an important component of the innate immune system.
Isabel Tobin, Guolong Zhang
openaire +3 more sources
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Th17, intestinal microbiota and the abnormal immune response in the pathogenesis of celiac disease [PDF]
, 2015 Celiac disease (CD) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the HLA-DQ2 or -DQ8 alleles.
Cicerone, Clelia +2 more
core
Hepcidin and Host Defense against Infectious Diseases. [PDF]
, 2015 Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas +3 more
core +1 more source
Nitric Oxide‐Generating Poly (allylamine hydrochloride) Coating on Biomedical Titanium Implant
Advanced Materials Interfaces, EarlyView.We report a metal‐free, nitric oxide (NO)‐generating coating in which poly(allylamine hydrochloride) (PAH) is covalently immobilized onto titanium. The coating catalyzes NO generation from the endogenous S‐nitrosothiol GSNO, retains activity after multiple reuse cycles and pH exposures, and maintains endothelial cell viability while modulating ...
Siti Nur Asyura Adzlan +7 more
wiley +1 more source
New horizons for host defense peptides and lantibiotics [PDF]
Current Opinion in Pharmacology, 2012 Antimicrobial peptides from either microbial sources, or based on host defense peptides (HDPs) from higher organisms, show promising activity against human pathogens. Lantibiotics have been extensively engineered by either molecular biology approaches or chemistry and both natural and modified entities have been shown to have good efficacy in animal ...
Michael John, Dawson, Richard W, Scott
openaire +2 more sources
Advanced Materials Technologies, EarlyView.This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li +7 more
wiley +1 more source
Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?
Frontiers in Immunology, 2012 Host defense peptides (HDPs) are an evolutionarily conserved component of the innate immune response found in all living species. They possess antimicrobial activities against a broad range of organisms including bacteria, fungi, eukaryotic parasites and
Sophie eCotton +6 more
doaj +1 more source
Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. [PDF]
PLoS ONE, 2010 Antimicrobial peptides play an important role in host defense against pathogens. Recently, phenol-soluble modulins (PSMs) from Staphylococcus epidermidis (S.
Anna L Cogen +9 more
doaj +1 more source